دورية أكاديمية
أعرض في EDS

Topical Nanoemulsions as Delivery Systems for Green Extracts of Pterocaulon balansae Aiming at the Treatment of Sporotrichosis.

التفاصيل البيبلوغرافية
العنوان: Topical Nanoemulsions as Delivery Systems for Green Extracts of Pterocaulon balansae Aiming at the Treatment of Sporotrichosis.
المؤلفون: Medeiros-Neves B; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil., Heidrich D; Departamento de Microbiologia, ICBS, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, Porto Alegre 90050-170, RS, Brazil., Schuh RS; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil., Brazil NT; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil., Fachel FNS; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil., Cassel E; Faculdade de Engenharia, Departamento de Engenharia Química, Pontifícia Universidade Católica do Rio Grande do Sul, Av. Ipiranga, 6681-Prédio 30-Sala 277, Porto Alegre 90619-900, RS, Brazil., Vargas RMF; Faculdade de Engenharia, Departamento de Engenharia Química, Pontifícia Universidade Católica do Rio Grande do Sul, Av. Ipiranga, 6681-Prédio 30-Sala 277, Porto Alegre 90619-900, RS, Brazil., Scroferneker ML; Departamento de Microbiologia, ICBS, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, Porto Alegre 90050-170, RS, Brazil., von Poser GL; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil., Koester LS; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil., Teixeira HF; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil.
المصدر: Pharmaceutics [Pharmaceutics] 2024 Apr 02; Vol. 16 (4). Date of Electronic Publication: 2024 Apr 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Coumarins are benzopyrones found in several plant genera, including Pterocaulon (Asteraceae). These compounds represent an important source of new treatments, especially as antimicrobial and antifungal agents. In this study, two coumarin-rich extracts from Pterocaulon balansae using green technologies were obtained through aqueous maceration (AE) and supercritical fluid extraction (SFE). Such extracts were incorporated into nanoemulsions (NAE and NSFE) composed of a medium-chain triglyceride oil core stabilized by phospholipids. The nanoemulsions exhibited droplet sizes between 127 and 162 nm, pH above 5.0, and viscosity of approximately 1.0 cP, properties compatible with the topical route. The coumarins permeation/retention from formulations through ear porcine skin using Franz-type diffusion cells were evaluated. Whatever the extract, coumarins were distributed in skin layers, especially in the dermis in both intact and impaired (tape stripping) skin. In addition, a significant increase in coumarins that reached up to the receptor fluid was observed for impaired skin, with increases of approximately threefold for NAE and fourfold for NSFE. Finally, antifungal activity of nanoemulsions was evaluated according to minimum inhibitory concentrations, and the values were 250 µg/mL for all strains tested. The overall results demonstrated the feasibility of incorporating P. balansae extracts into nanoemulsions and showed a potential alternative for the treatment of sporotrichosis.
References: Pharmaceutics. 2023 Nov 25;15(12):. (PMID: 38140014)
Mycopathologia. 2022 Aug;187(4):407-411. (PMID: 35776287)
Int J Nanomedicine. 2014 Oct 09;9:4737-47. (PMID: 25336951)
Antimicrob Agents Chemother. 2001 Dec;45(12):3310-21. (PMID: 11709302)
J Control Release. 2017 Apr 28;252:28-49. (PMID: 28279798)
Pharmaceutics. 2017 Sep 21;9(4):. (PMID: 28934172)
J Ethnopharmacol. 2018 Oct 5;224:451-464. (PMID: 29913300)
Eur J Pharm Biopharm. 2021 Dec;169:29-36. (PMID: 34508806)
J Multidiscip Healthc. 2022 Aug 27;15:1819-1840. (PMID: 36060421)
J Control Release. 2010 Feb 15;141(3):277-99. (PMID: 19850095)
RSC Med Chem. 2023 Oct 20;15(1):10-54. (PMID: 38283214)
Mol Divers. 2020 Nov;24(4):1367-1383. (PMID: 31520360)
Food Sci Biotechnol. 2023 Jun 23;32(13):1763-1782. (PMID: 37781053)
Microorganisms. 2022 Oct 30;10(11):. (PMID: 36363744)
Biomed Res Int. 2013;2013:963248. (PMID: 23586066)
Dermatol Res Pract. 2014;2014:272376. (PMID: 25614735)
AAPS PharmSciTech. 2024 Feb 27;25(3):46. (PMID: 38413430)
J Mycol Med. 2011 Sep;21(3):169-72. (PMID: 24451558)
Pharmaceutics. 2023 Jul 20;15(7):. (PMID: 37514175)
Mini Rev Med Chem. 2018;18(2):113-141. (PMID: 27488585)
معلومات مُعتمدة: 420025/2021-9; National Council for Scientific and Technological Development; 316794/2021-0 National Council for Scientific and Technological Development; Finance Code 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: Sporotrix schenckii; coumarin; high-pressure homogenization; nanoemulsion; permeation/retention assay
تواريخ الأحداث: Date Created: 20240427 Latest Revision: 20240429
رمز التحديث: 20240429
مُعرف محوري في PubMed: PMC11054391
DOI: 10.3390/pharmaceutics16040492
PMID: 38675153
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics16040492