دورية أكاديمية
أعرض في EDS

Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX.

التفاصيل البيبلوغرافية
العنوان: Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX.
المؤلفون: Ohno R; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Mainka M; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Kirchhoff R; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Hartung NM; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Apr 12; Vol. 29 (8). Date of Electronic Publication: 2024 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Arachidonate 15-Lipoxygenase*/metabolism , Liver X Receptors*/metabolism , Liver X Receptors*/agonists , Macrophages*/metabolism , Macrophages*/drug effects , Oxylipins*/metabolism, Humans ; Anti-Inflammatory Agents/pharmacology ; Sterols/pharmacology ; Sterols/metabolism
مستخلص: The understanding of the role of LXR in the regulation of macrophages during inflammation is emerging. Here, we show that LXR agonist T09 specifically increases 15-LOX abundance in primary human M2 macrophages. In time- and dose-dependent incubations with T09, an increase of 3-fold for ALOX15 and up to 15-fold for 15-LOX-derived oxylipins was observed. In addition, LXR activation has no or moderate effects on the abundance of macrophage marker proteins such as TLR2, TLR4, PPARγ, and IL-1RII, as well as surface markers (CD14, CD86, and CD163). Stimulation of M2-like macrophages with FXR and RXR agonists leads to moderate ALOX15 induction, probably due to side activity on LXR. Finally, desmosterol, 24( S ),25-Ep cholesterol and 22( R )-OH cholesterol were identified as potent endogenous LXR ligands leading to an ALOX15 induction. LXR-mediated ALOX15 regulation is a new link between the two lipid mediator classes sterols, and oxylipins, possibly being an important tool in inflammatory regulation through anti-inflammatory oxylipins.
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معلومات مُعتمدة: Sche 1801 Deutsche Forschungsgemeinschaft
فهرسة مساهمة: Keywords: eicosanoids; lipoxygenase; liver X receptor; macrophages; oxylipins; specialized pro-resolving mediators
المشرفين على المادة: 0 (ALOX15 protein, human)
تواريخ الأحداث: Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240520
رمز التحديث: 20240520
مُعرف محوري في PubMed: PMC11052137
DOI: 10.3390/molecules29081745
PMID: 38675565
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29081745