دورية أكاديمية
Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX.
العنوان: | Sterol Derivatives Specifically Increase Anti-Inflammatory Oxylipin Formation in M2-like Macrophages by LXR-Mediated Induction of 15-LOX. |
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المؤلفون: | Ohno R; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Mainka M; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Kirchhoff R; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Hartung NM; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany., Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany. |
المصدر: | Molecules (Basel, Switzerland) [Molecules] 2024 Apr 12; Vol. 29 (8). Date of Electronic Publication: 2024 Apr 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
مواضيع طبية MeSH: | Arachidonate 15-Lipoxygenase*/metabolism , Liver X Receptors*/metabolism , Liver X Receptors*/agonists , Macrophages*/metabolism , Macrophages*/drug effects , Oxylipins*/metabolism, Humans ; Anti-Inflammatory Agents/pharmacology ; Sterols/pharmacology ; Sterols/metabolism |
مستخلص: | The understanding of the role of LXR in the regulation of macrophages during inflammation is emerging. Here, we show that LXR agonist T09 specifically increases 15-LOX abundance in primary human M2 macrophages. In time- and dose-dependent incubations with T09, an increase of 3-fold for ALOX15 and up to 15-fold for 15-LOX-derived oxylipins was observed. In addition, LXR activation has no or moderate effects on the abundance of macrophage marker proteins such as TLR2, TLR4, PPARγ, and IL-1RII, as well as surface markers (CD14, CD86, and CD163). Stimulation of M2-like macrophages with FXR and RXR agonists leads to moderate ALOX15 induction, probably due to side activity on LXR. Finally, desmosterol, 24( S ),25-Ep cholesterol and 22( R )-OH cholesterol were identified as potent endogenous LXR ligands leading to an ALOX15 induction. LXR-mediated ALOX15 regulation is a new link between the two lipid mediator classes sterols, and oxylipins, possibly being an important tool in inflammatory regulation through anti-inflammatory oxylipins. |
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معلومات مُعتمدة: | Sche 1801 Deutsche Forschungsgemeinschaft |
فهرسة مساهمة: | Keywords: eicosanoids; lipoxygenase; liver X receptor; macrophages; oxylipins; specialized pro-resolving mediators |
المشرفين على المادة: | 0 (ALOX15 protein, human) |
تواريخ الأحداث: | Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240520 |
رمز التحديث: | 20240520 |
مُعرف محوري في PubMed: | PMC11052137 |
DOI: | 10.3390/molecules29081745 |
PMID: | 38675565 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1420-3049 |
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DOI: | 10.3390/molecules29081745 |