دورية أكاديمية
أعرض في EDS

Geographical Expansion of Avian Metapneumovirus Subtype B: First Detection and Molecular Characterization of Avian Metapneumovirus Subtype B in US Poultry.

التفاصيل البيبلوغرافية
العنوان: Geographical Expansion of Avian Metapneumovirus Subtype B: First Detection and Molecular Characterization of Avian Metapneumovirus Subtype B in US Poultry.
المؤلفون: Luqman M; Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, College of Agriculture, Food & Environmental Sciences, South Dakota State University, Brookings, SD 57007, USA., Duhan N; Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, College of Agriculture, Food & Environmental Sciences, South Dakota State University, Brookings, SD 57007, USA., Temeeyasen G; Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, College of Agriculture, Food & Environmental Sciences, South Dakota State University, Brookings, SD 57007, USA., Selim M; Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, College of Agriculture, Food & Environmental Sciences, South Dakota State University, Brookings, SD 57007, USA., Jangra S; Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, College of Agriculture, Food & Environmental Sciences, South Dakota State University, Brookings, SD 57007, USA., Mor SK; Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, College of Agriculture, Food & Environmental Sciences, South Dakota State University, Brookings, SD 57007, USA.
المصدر: Viruses [Viruses] 2024 Mar 26; Vol. 16 (4). Date of Electronic Publication: 2024 Mar 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Metapneumovirus*/genetics , Metapneumovirus*/classification , Metapneumovirus*/isolation & purification , Paramyxoviridae Infections*/veterinary , Paramyxoviridae Infections*/virology , Paramyxoviridae Infections*/epidemiology , Poultry Diseases*/virology , Poultry Diseases*/epidemiology , Phylogeny* , Turkeys*/virology , Genome, Viral*, Animals ; United States/epidemiology ; Chickens/virology ; Poultry/virology ; Metagenomics ; Disease Outbreaks/veterinary
مستخلص: Avian metapneumovirus (aMPV), classified within the Pneumoviridae family, wreaks havoc on poultry health. It typically causes upper respiratory tract and reproductive tract infections, mainly in turkeys, chickens, and ducks. Four subtypes of AMPV (A, B, C, D) and two unclassified subtypes have been identified, of which subtypes A and B are widely distributed across the world. In January 2024, an outbreak of severe respiratory disease occurred on turkey and chicken farms across different states in the US. Metagenomics sequencing of selected tissue and swab samples confirmed the presence of aMPV subtype B. Subsequently, all samples were screened using an aMPV subtype A and B multiplex real-time RT-PCR kit. Of the 221 farms, 124 (56%) were found to be positive for aMPV-B. All samples were negative for subtype A. Six whole genomes were assembled, five from turkeys and one from chickens; all six assembled genomes showed 99.29 to 99.98% nucleotide identity, indicating a clonal expansion event for aMPV-B within the country. In addition, all six sequences showed 97.74 to 98.58% nucleotide identity with previously reported subtype B sequences, e.g., VCO3/60616, Hungary/657/4, and BR/1890/E1/19. In comparison to these two reference strains, the study sequences showed unique 49-62 amino acid changes across the genome, with maximum changes in glycoprotein (G). One unique AA change from T (Threonine) to I (Isoleucine) at position 153 in G protein was reported only in the chicken aMPV sequence, which differentiated it from turkey sequences. The twelve unique AA changes along with change in polarity of the G protein may indicate that these unique changes played a role in the adaptation of this virus in the US poultry. This is the first documented report of aMPV subtype B in US poultry, highlighting the need for further investigations into its genotypic characterization, pathogenesis, and evolutionary dynamics.
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فهرسة مساهمة: Keywords: Avian metapneumovirus; NGS; phylogeny; poultry; respiratory disease; subtype-B
تواريخ الأحداث: Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240522
رمز التحديث: 20240522
مُعرف محوري في PubMed: PMC11054003
DOI: 10.3390/v16040508
PMID: 38675851
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v16040508