دورية أكاديمية
Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS.
| العنوان: | Omega-3 Fatty Acids and Risk of Ischemic Stroke in REGARDS. |
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| المؤلفون: | Ament Z; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., Patki A; Department of Epidemiology, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Bhave VM; Harvard Medical School, Boston, MA, USA., Kijpaisalratana N; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Division of Neurology, Department of Medicine and Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Jones AC; Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, USA., Couch CA; Department of Epidemiology, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Stanton RJ; Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH, USA., Rist PM; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA., Judd SE; Department of Biostatistics, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Long DL; Department of Biostatistics, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Irvin MR; Department of Epidemiology, School of Public Health at the University of Alabama at Birmingham, Birmingham, AL, USA., Kimberly WT; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. wtkimberly@mgh.harvard.edu.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. wtkimberly@mgh.harvard.edu. |
| المصدر: | Translational stroke research [Transl Stroke Res] 2024 Apr 27. Date of Electronic Publication: 2024 Apr 27. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Springer |
| مستخلص: | We examined associations between lipidomic profiles and incident ischemic stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Plasma lipids (n = 195) were measured from baseline blood samples, and lipids were consolidated into underlying factors using exploratory factor analysis. Cox proportional hazards models were used to test associations between lipid factors and incident stroke, linear regressions to determine associations between dietary intake and lipid factors, and the inverse odds ratio weighting (IORW) approach to test mediation. The study followed participants over a median (IQR) of 7 (3.4-11) years, and the case-cohort substudy included 1075 incident ischemic stroke and 968 non-stroke participants. One lipid factor, enriched for docosahexaenoic acid (DHA, an omega-3 fatty acid), was inversely associated with stroke risk in a base model (HR = 0.84; 95%CI 0.79-0.90; P = 8.33 × 10 -8 ) and fully adjusted model (HR = 0.88; 95%CI 0.83-0.94; P = 2.79 × 10 -4 ). This factor was associated with a healthy diet pattern (β = 0.21; 95%CI 0.12-0.30; P = 2.06 × 10 -6 ), specifically with fish intake (β = 1.96; 95%CI 0.95-2.96; P = 1.36 × 10 -4 ). DHA was a mediator between fish intake and incident ischemic stroke (30% P = 5.78 × 10 -3 ). Taken together, DHA-containing plasma lipids were inversely associated with incident ischemic stroke and mediated the relationship between fish intake and stroke risk. (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| معلومات مُعتمدة: | U01 NS041588 United States NS NINDS NIH HHS; U01 NS041588 United States NS NINDS NIH HHS; U01 NS041588 United States AG NIA NIH HHS; U01 NS041588 United States AG NIA NIH HHS; R01 NS099209 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: Docosahexaenoic acid (DHA); Epidemiology; Exploratory factor analysis; Incident ischemic stroke; Omega-3 |
| تواريخ الأحداث: | Date Created: 20240427 Latest Revision: 20240427 |
| رمز التحديث: | 20240428 |
| DOI: | 10.1007/s12975-024-01256-7 |
| PMID: | 38676880 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1868-601X |
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| DOI: | 10.1007/s12975-024-01256-7 |