دورية أكاديمية
Biodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering.
العنوان: | Biodegradable electrospun poly(L-lactide-co-ε-caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering. |
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المؤلفون: | de Souza JR; Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.; Department of Dental Materials and Prosthodontics, Institute of Science and Technology of São José dos Campos, São Paulo State University (UNESP), São José dos Campos, SP, Brazil., Cardoso LM; Department of Dental Materials and Prosthodontics, Institute of Science and Technology of São José dos Campos, São Paulo State University (UNESP), São José dos Campos, SP, Brazil., de Toledo PTA; Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), Araçatuba, SP, Brazil., Rahimnejad M; Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA., Kito LT; Department of Materials Manufacture and Automation, Technological Institute of Aeronautics (ITA), São José dos Campos, SP, Brazil., Thim GP; Department of Materials Manufacture and Automation, Technological Institute of Aeronautics (ITA), São José dos Campos, SP, Brazil., Campos TMB; Department of Prosthodontics and Periodontology, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil., Borges ALS; Department of Dental Materials and Prosthodontics, Institute of Science and Technology of São José dos Campos, São Paulo State University (UNESP), São José dos Campos, SP, Brazil., Bottino MC; Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, Michigan, USA. |
المصدر: | Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2024 May; Vol. 112 (5), pp. e35406. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234238 Publication Model: Print Cited Medium: Internet ISSN: 1552-4981 (Electronic) Linking ISSN: 15524973 NLM ISO Abbreviation: J Biomed Mater Res B Appl Biomater Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Hoboken, NJ : John Wiley & Sons, c2003- |
مواضيع طبية MeSH: | Tissue Engineering* , Polyethylene Glycols*/chemistry , Polyesters*/chemistry , Tissue Scaffolds*/chemistry , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/metabolism, Humans ; Glass/chemistry ; Materials Testing |
مستخلص: | The field of tissue engineering has witnessed significant advancements in recent years, driven by the pursuit of innovative solutions to address the challenges of bone regeneration. In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L-lactide-co-ε-caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate-chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone-derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently enhancing hydrophilicity. Thermal gravimetric analysis confirmed the efficient incorporation of BG, with the scaffolds demonstrating thermal stability up to 250°C. Mechanical testing revealed enhanced tensile strength and Young's modulus in the presence of BG; however, the elongation at break decreased. Cell viability assays demonstrated improved cytocompatibility, especially in the PLCL/PEG+BG group. Alizarin red staining indicated enhanced osteoinductive potential, and fluorescence analysis confirmed increased cell adhesion in the PLCL/PEG+BG group. Our findings suggest that the PLCL/PEG/BG composite scaffold holds promise as an advanced biomaterial for bone tissue engineering. (© 2024 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC.) |
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معلومات مُعتمدة: | R01 DE031476 United States DE NIDCR NIH HHS; R01DE031476 National Institutes of Health (NIH) - National Institute of Dental and Craniofacial Research |
فهرسة مساهمة: | Keywords: bioactive glass; biopolymers; bone regeneration; electrospinning; scaffolds; tissue engineering |
المشرفين على المادة: | 3WJQ0SDW1A (Polyethylene Glycols) 0 (Polyesters) 70524-20-8 (lactide-caprolactone copolymer) |
تواريخ الأحداث: | Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240801 |
رمز التحديث: | 20240801 |
مُعرف محوري في PubMed: | PMC11288622 |
DOI: | 10.1002/jbm.b.35406 |
PMID: | 38676957 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1552-4981 |
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DOI: | 10.1002/jbm.b.35406 |