دورية أكاديمية
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The influence of thioether-substituted ligands in dicopper(II) complexes: Enhancing oxidation and biological activities.

التفاصيل البيبلوغرافية
العنوان: The influence of thioether-substituted ligands in dicopper(II) complexes: Enhancing oxidation and biological activities.
المؤلفون: Durigon DC; Departamento de Química, Universidade Federal de Santa Catarina, UFSC, CEP 88040-900 Florianópolis, SC, Brazil., Glitz VA; Departamento de Química, Universidade Federal de Santa Catarina, UFSC, CEP 88040-900 Florianópolis, SC, Brazil., Pimenta BF; Laboratório de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, UFSC, CEP 88040-900 Florianópolis, SC, Brazil., Guedes AMV; Departamento de Química, Universidade Federal do Rio de Janeiro, UFRJ, CEP 21941-901 Rio de Janeiro, RJ, Brazil., Silva JVO; Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, UEM, CEP 87020-900 Maringá, PR, Brazil., Bella Cruz CC; Centro de Ensino em Ciências da Saúde, Universidade do Vale do Itajaí, Univali, CEP 88302-901 Itajaí, SC, Brazil., Andrade LM; Departamento de Genética, Ecologia e Evolução and Departamento de Física, Universidade Federal de Minas Gerais, UFMG, CEP 31270-901 Belo Horizonte, MG, Brazil., Pereira-Maia EC; Departamento de Química, Universidade Federal de Minas Gerais, UFMG, CEP 31270-901, Belo Horizonte, MG, Brazil., Mikcha JMG; Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, UEM, CEP 87020-900 Maringá, PR, Brazil., Bella Cruz A; Centro de Ensino em Ciências da Saúde, Universidade do Vale do Itajaí, Univali, CEP 88302-901 Itajaí, SC, Brazil., Xavier FR; Departamento de Química, Universidade do Estado de Santa Catarina, UDESC, CEP 89219-710 Joinville, SC, Brazil., Terenzi HF; Laboratório de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, UFSC, CEP 88040-900 Florianópolis, SC, Brazil., Poneti G; Departamento de Química, Universidade Federal do Rio de Janeiro, UFRJ, CEP 21941-901 Rio de Janeiro, RJ, Brazil; Dipartimento di Scienze Ecologiche e Biologiche, Università degli Studi della Tuscia, Largo dell'Università, 01100 Viterbo, Italy., Ribeiro RR; Departamento de Química, Universidade Federal do Paraná, UFPR, CEP 81531-980 Curitiba, PR, Brazil., Nordlander E; Chemical Physics, Department of Chemistry, Lund University, Box 124, SE-221 00 Lund, Sweden., Caramori GF; Departamento de Química, Universidade Federal de Santa Catarina, UFSC, CEP 88040-900 Florianópolis, SC, Brazil., Bortoluzzi AJ; Departamento de Química, Universidade Federal de Santa Catarina, UFSC, CEP 88040-900 Florianópolis, SC, Brazil., Peralta RA; Departamento de Química, Universidade Federal de Santa Catarina, UFSC, CEP 88040-900 Florianópolis, SC, Brazil. Electronic address: rosely.peralta@ufsc.br.
المصدر: Journal of inorganic biochemistry [J Inorg Biochem] 2024 Jul; Vol. 256, pp. 112573. Date of Electronic Publication: 2024 Apr 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, Elsevier.
مواضيع طبية MeSH: Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Oxidation-Reduction* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Humans ; Ligands ; Sulfides/chemistry ; Sulfides/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/chemical synthesis ; Platinum/chemistry ; Platinum/pharmacology ; Cell Line, Tumor
مستخلص: This paper describes the synthesis, structural analysis, as well as the magnetic and spectroscopic characterizations of three new dicopper(II) complexes with dinucleating phenol-based ligands containing different thioether donor substituents: aromatic (1), aliphatic (2) or thiophene (3). Temperature-dependent magnetometry reveals the presence of antiferromagnetic coupling for 1 and 3 (J = -2.27 cm -1 and -5.01 cm -1 , respectively, H = -2JS 1 S 2 ) and ferromagnetic coupling for 2 (J = 5.72 cm -1 ). Broken symmetry DFT calculations attribute this behavior to a major contribution from the d z2 orbitals for 1 and 3, and from the d x2-y2 orbitals for 2, along with the p orbitals of the oxygens. The bioinspired catalytic activities of these complexes related to catechol oxidase were studied using 3,5-di-tert-butylcatechol as substrate. The order of catalytic rates for the substrate oxidation follows the trend 1 > 2 > 3 with k cat of (90.79 ± 2.90) × 10 -3 for 1, (64.21 ± 0.99) × 10 -3 for 2 and (14.20 ± 0.32) × 10 -3  s -1 for 3. The complexes also cleave DNA through an oxidative mechanism with minor-groove preference, as indicated by experimental and molecular docking assays. Antimicrobial potential of these highly active complexes has shown that 3 inhibits both Staphylococcus aureus bacterium and Epidermophyton floccosum fungus. Notably, the complexes were found to be nontoxic to normal cells but exhibited cytotoxicity against epidermoid carcinoma cells, surpassing the activity of the metallodrug cisplatin. This research shows the multifaceted properties of these complexes, making them promising candidates for various applications in catalysis, nucleic acids research, and antimicrobial activities.
Competing Interests: Declaration of competing interest There are no conflicts of interest to declare.
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Anticancer activity; Antimicrobial activity; Catecholase Activity; DNA cleavage; Dicopper(II) complexes; Thioether ligands
المشرفين على المادة: 0 (Coordination Complexes)
0 (Antineoplastic Agents)
0 (Ligands)
0 (Sulfides)
0 (Anti-Bacterial Agents)
49DFR088MY (Platinum)
تواريخ الأحداث: Date Created: 20240428 Date Completed: 20240509 Latest Revision: 20240509
رمز التحديث: 20240510
DOI: 10.1016/j.jinorgbio.2024.112573
PMID: 38678913
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3344
DOI:10.1016/j.jinorgbio.2024.112573