Powerful Approach for New Drugs as Antibacterial Agents via Molecular Docking and In Vitro Studies of Some New Cyclic Imides and Quinazoline-2,5-diones.

التفاصيل البيبلوغرافية
العنوان:	Powerful Approach for New Drugs as Antibacterial Agents via Molecular Docking and In Vitro Studies of Some New Cyclic Imides and Quinazoline-2,5-diones.
المؤلفون:	Nasser Binjawhar D; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Abu Ali OA; Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Alqahtani AS; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), P.O. Box 90950, Riyadh 11623, Saudi Arabia., Fayad E; Department of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Abo-Bakr AM; Chemistry Department, Faculty of Science, South Valley University, P.O. Box 83523, Qena 83523, Egypt., Mekhael AM; Cotton Leaf Worm Department, Plant Protection Research Institute, Agriculture Research Center, P.O. Box 12619, Giza 12611, Egypt., Sadek FM; Radiation Sciences Department, Medical Research Institution, Alexandria University, P.O. Box 21500, Alexandria 5424041, Egypt.
المصدر:	ACS omega [ACS Omega] 2024 Apr 10; Vol. 9 (16), pp. 18566-18575. Date of Electronic Publication: 2024 Apr 10 (Print Publication: 2024).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: Washington, D.C. : American Chemical Society, [2016]-
مستخلص:	We generated novel elven 1,2,3,6-tetrahydrophthalimides and tetrahydroquinazoline derivatives from 1,2,3,6-tetrahydrophthalic anhydride ( 1 ) in response to our interest in using the anhydrides to produce heterocyclic nitrogen compounds. The elemental and spectral analyses of the produced compounds validated the recommended configurations and MOE 2014.09 (Molecular Operating Environment) computations were used to perform their in silico analysis. The synthesized compounds have been analyzed and put through various experiments, including in vitro and in silico methods to assess their biological activity against Escherichia coli Penicillin-Binding Protein 3 ( PBP3 ) and Staphylococcus aureus Penicillin-Binding Protein 2 ( PBP2 ), among these compounds showing promising data as antibacterial drugs. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
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تواريخ الأحداث:	Date Created: 20240429 Latest Revision: 20240430
رمز التحديث:	20240430
مُعرف محوري في PubMed:	PMC11044208
DOI:	10.1021/acsomega.4c01176
PMID:	38680340
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	2470-1343
DOI:	10.1021/acsomega.4c01176