دورية أكاديمية
أعرض في EDS

Impact of gadolinium-based MRI contrast agent and local anesthetics co-administration on chondrogenic gadolinium uptake and cytotoxicity.

التفاصيل البيبلوغرافية
العنوان: Impact of gadolinium-based MRI contrast agent and local anesthetics co-administration on chondrogenic gadolinium uptake and cytotoxicity.
المؤلفون: Zimmerer A; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Germany.; Diakonieklinikum Stuttgart, Department of Orthopaedic and Trauma Surgery, Orthopädische Klinik Paulinenhilfe, Stuttgart, Germany., Schulze F; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Germany., Gebhardt S; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Germany., Huesker K; Immunology Department, Institute for Medical Diagnostics (IMD), Berlin, Germany., Stobbe D; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Germany., Grolimund D; Swiss Light Source, Paul Scherrer Institute, Villigen, Switzerland., Hesse B; Xploraytion GmbH, Berlin, Germany.; ESRF-The European Synchrotron, Grenoble, France., Wassilew GI; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Germany., Schoon J; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Germany.
المصدر: Heliyon [Heliyon] 2024 Apr 15; Vol. 10 (8), pp. e29719. Date of Electronic Publication: 2024 Apr 15 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: The gadolinium-based contrast agent DOTA-Gd is clinically used in combination with local anesthetics for direct magnetic resonance arthrography. It remains unclear whether gadolinium uptake into cartilage is influenced by co-administration of bupivacaine or ropivacaine and whether DOTA-Gd alters their chondrotoxicity. Gadolinium quantification of chondrogenic spheroids revealed enhanced gadolinium uptake after simultaneous exposure to local anesthetics. Analyses of the spatial gadolinium distribution using synchrotron X-ray-fluorescence scanning indicates gadolinium exposed chondrocytes. In vitro exposure to DOTA-Gd does not alter viability and proliferation of human chondrocytes and the chondrotoxic potential of the anesthetics. Reduced viability induced by ropivacaine was found to be reversible, while exposure to bupivacaine leads to irreversible cell death. Our data suggest that ropivacaine is more tolerable than bupivacaine and that DOTA-Gd exposure does not alter the cytotoxicity of both anesthetics. Enhanced gadolinium uptake into cartilage due to co-administration of anesthetics should find attention.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors. Published by Elsevier Ltd.)
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تواريخ الأحداث: Date Created: 20240429 Latest Revision: 20240430
رمز التحديث: 20240430
مُعرف محوري في PubMed: PMC11053198
DOI: 10.1016/j.heliyon.2024.e29719
PMID: 38681575
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2024.e29719