دورية أكاديمية
أعرض في EDS

Cardiovascular Outcomes Among Patients with Acute Coronary Syndromes and Diabetes: Results from ACS QUIK Trial in India.

التفاصيل البيبلوغرافية
العنوان: Cardiovascular Outcomes Among Patients with Acute Coronary Syndromes and Diabetes: Results from ACS QUIK Trial in India.
المؤلفون: Alfaddagh A; Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, US., Khraishah H; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US., Romeo GR; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.; Joslin Diabetes Center, Harvard Medical School, Boston, MA, US., Kassab MB; Cardiovascular research center, Massachusetts General Hospital, Boston, MA, US., McMillan Z; Department of Anesthesiology, Division of Critical Care, UC San Diego, San Diego, CA, USA., Chandra-Strobos N; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, US., Blumenthal R; Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, US., Albaghdadi M; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US.
المصدر: Global heart [Glob Heart] 2024 Apr 24; Vol. 19 (1), pp. 37. Date of Electronic Publication: 2024 Apr 24 (Print Publication: 2024).
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Ubiquity Press Country of Publication: England NLM ID: 101584391 Publication Model: eCollection Cited Medium: Internet ISSN: 2211-8179 (Electronic) Linking ISSN: 22118160 NLM ISO Abbreviation: Glob Heart Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [London] : Ubiquity Press
Original Publication: [Oxford] : Elsevier Ltd.
مواضيع طبية MeSH: Acute Coronary Syndrome*/epidemiology , Acute Coronary Syndrome*/therapy, Humans ; Female ; Male ; India/epidemiology ; Middle Aged ; Diabetes Mellitus/epidemiology ; Hospital Mortality/trends ; Aged ; Percutaneous Coronary Intervention/statistics & numerical data ; Survival Rate/trends ; Risk Factors ; Follow-Up Studies
مستخلص: Background: Despite cardiovascular disease being the leading cause of death in India, limited data exist regarding the factors associated with outcomes in patients with diabetes who suffer acute myocardial infarction (AMI).
Methods: We examined 21,374 patients with AMI enrolled in the ACS QUIK trial. We compared in-hospital and 30-day major adverse cardiac events including death, re-infarction, stroke, or major bleeding in those with and without diabetes. The associations between diabetes and cardiac outcomes were adjusted for presentation and in-hospital management using logistic regression.
Results: Mean ± SD age was 60.1 ± 12.0 years, 24.3% were females, and 44.4% had diabetes. Those with diabetes were more likely to be older, female, hypertensive, and have higher Killip class but less likely to present with STEMI. Patients with diabetes had longer symptoms onset-to-arrival (median 225 vs 290 min; P < 0.001) and, in case of STEMI, longer door-to-balloon times (median, 75 vs 91 min; P < 0.001). Diabetes was independently associated with higher in-hospital death (adjusted odds ratio [aOR], 1.46; 95% CI, 1.12-1.89), in-hospital reinfarction (aOR, 1.52; 95% CI, 1.15-2.02), 30-day MACE (aOR, 1.33; 95% CI, 1.14-1.55) and 30-day death (aOR, 1.40; 95%CI, 1.16-1.69) but not 30-day stroke or 30-day major bleeding.
Conclusion: Among patients presenting with AMI in Kerala, India, a considerable proportion has diabetes and are at increased risk for in-hospital and 30-day adverse cardiovascular outcomes. Increased awareness of the increased cardiovascular risk and attention to the implementation of established cardiovascular therapies are indicated for patients with diabetes in lower-middle-income countries who develop AMI.
Clinical Trial Registration: ClinicalTrials.gov Unique identifier: NCT02256658.
Competing Interests: The authors have no competing interests to declare.
(Copyright: © 2024 The Author(s).)
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فهرسة مساهمة: Keywords: Diabetes; India; cardiovascular outcomes; lower-middle income country; myocardial infarction
تواريخ الأحداث: Date Created: 20240429 Date Completed: 20240429 Latest Revision: 20240522
رمز التحديث: 20240523
مُعرف محوري في PubMed: PMC11049669
DOI: 10.5334/gh.1290
PMID: 38681971
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-8179
DOI:10.5334/gh.1290