دورية أكاديمية
Conservation of a Chromosome 8 Inversion and Exon Mutations Confirm Common Gulonolactone Oxidase Gene Evolution Among Primates, Including H. Neanderthalensis.
| العنوان: | Conservation of a Chromosome 8 Inversion and Exon Mutations Confirm Common Gulonolactone Oxidase Gene Evolution Among Primates, Including H. Neanderthalensis. |
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| المؤلفون: | Mansueto A; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA.; Department of Biological Sciences, Vanderbilt University, Nashvile, TN, USA., Good DJ; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, USA. goodd@vt.edu.; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, 1981 Kraft Drive (0913), ILSB Room 1020, Blacksburg, VA, 24060, USA. goodd@vt.edu. |
| المصدر: | Journal of molecular evolution [J Mol Evol] 2024 Jun; Vol. 92 (3), pp. 266-277. Date of Electronic Publication: 2024 Apr 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0360051 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1432 (Electronic) Linking ISSN: 00222844 NLM ISO Abbreviation: J Mol Evol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Evolution, Molecular* , Exons*/genetics , Phylogeny* , Primates*/genetics , Mutation*/genetics , L-Gulonolactone Oxidase*/genetics , Chromosome Inversion*/genetics, Animals ; Humans ; Pseudogenes/genetics ; Conserved Sequence/genetics |
| مستخلص: | Ascorbic acid functions as an antioxidant and facilitates other biochemical processes such as collagen triple helix formation, and iron uptake by cells. Animals which endogenously produce ascorbic acid have a functional gulonolactone oxidase gene (GULO); however, humans have a GULO pseudogene (GULOP) and depend on dietary ascorbic acid. In this study, the conservation of GULOP sequences in the primate haplorhini suborder were investigated and compared to the GULO sequences belonging to the primates strepsirrhini suborder. Phylogenetic analysis suggested that the conserved GULOP exons in the haplorhini primates experienced a high rate of mutations following the haplorhini/strepsirrhini divergence. This high mutation rate has decreased during the evolution of the haplorhini primates. Additionally, indels of the haplorhini GULOP sequences were conserved across the suborder. A separate analysis for GULO sequences and well-conserved GULOP sequences focusing on placental mammals identified an in-frame GULO sequence in the Brazilian guinea pig, and a potential GULOP sequence in the pika. Similar to haplorhini primates, the guinea pig and lagomorph species have experienced a high substitution rate when compared to the mammals used in this study. A shared synteny to examine the conservation of local genes near GULO/GULOP identified a conserved inversion around the GULO/GULOP locus between the haplorhini and strepsirrhini primates. Fischer's exact test did not support an association between GULOP and the chromosomal inversion. Mauve alignment showed that the inversion of the length of the syntenic block that the GULO/GULOP genes belonged to was variable. However, there were frequent rearrangements around ~ 2 million base pairs adjacent to GULOP involving the KIF13B and MSRA genes. These data may suggest that genes acquiring deleterious mutations in the coding sequence may respond to these deleterious mutations with rapid substitution rates. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Ascorbic acid; GULO; GULOP; Neanderthal; Phylogeny; Primates; Vitamin C |
| المشرفين على المادة: | EC 1.1.3.8 (L-Gulonolactone Oxidase) |
| تواريخ الأحداث: | Date Created: 20240429 Date Completed: 20240612 Latest Revision: 20240620 |
| رمز التحديث: | 20240621 |
| مُعرف محوري في PubMed: | PMC11169010 |
| DOI: | 10.1007/s00239-024-10165-0 |
| PMID: | 38683367 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-1432 |
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| DOI: | 10.1007/s00239-024-10165-0 |