التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and bioevaluation of water-soluble β -cyclodextrin-diterpene acid conjugates. |
| المؤلفون: |
LiWen H; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Yanliang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Tretyakova EV; Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia., Smirnova AA; Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia., Kazakova OB; Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia., Xiao S; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.; Shenzhen Bay Laboratory, Gaoke International Innovation Center, Shenzhen, China.; Ningbo Institute of Marine Medicine, Peking University, Ningbo, China. |
| المصدر: |
Natural product research [Nat Prod Res] 2024 Apr 29, pp. 1-9. Date of Electronic Publication: 2024 Apr 29. |
| Publication Model: |
Ahead of Print |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مستخلص: |
A series of β -cyclodextrin ( β -CD)-conjugates were prepared by combining three abietane-type diterpene acids with two azide-functionalized β -CDs via click chemistry, and the antiviral activity against wild-type and omicron SARS-CoV-2 spike pseudovirus as well as the antibacterial activity against Escherichia coli were investigated. All the synthesised conjugates exhibited no significant cytotoxicity to BHK-21-hACE2 cells with cell viability over 80% at concentration of 15 µ M. Among the conjugates, the heptavalent β -CD-dehydroabietic acid conjugate 6b exhibited higher anti-SARS-CoV-2 activity against the omicron variant compared to the other conjugates. This study suggested that the multivalent diterpene acid derivatives may have potential application against coronaviruses as entry inhibitors. |
| فهرسة مساهمة: |
Keywords: Abietane diterpenoids; abietic acid; antibacterial; anticoronavirus; dehydroabietic acid; dihydroquinopimaric acid; synthesis; β-cyclodextrin |
| تواريخ الأحداث: |
Date Created: 20240429 Latest Revision: 20240429 |
| رمز التحديث: |
20240501 |
| DOI: |
10.1080/14786419.2024.2347449 |
| PMID: |
38684026 |
| قاعدة البيانات: |
MEDLINE |
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