دورية أكاديمية
أعرض في EDS

Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study.

التفاصيل البيبلوغرافية
العنوان: Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study.
المؤلفون: Longo BC; Department of Dentistry, State University of Maringá (UEM), Av Mandacaru, 1550, Campus Universitário, Maringá, PR, Brazil., Rohling IB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, PR, Brazil., Silva PLMOE; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, PR, Brazil., Paz HES; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Casarin RCV; Department of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil., Souza MDB; Department of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, PR, Brazil., Silva CO; Department of Dentistry, State University of Maringá (UEM), Av Mandacaru, 1550, Campus Universitário, Maringá, PR, Brazil. prof.cleversonsilva@gmail.com.
المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2024 Apr 29; Vol. 32 (5), pp. 316. Date of Electronic Publication: 2024 Apr 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1993-
مواضيع طبية MeSH: Dental Caries*/epidemiology , Neoplasms*/drug therapy , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/therapeutic use , Streptococcus mutans*/isolation & purification, Humans ; Male ; Female ; Risk Factors ; Retrospective Studies ; Child ; Adolescent ; Cohort Studies ; Saliva/microbiology ; Case-Control Studies ; DMF Index ; Oral Hygiene/methods
مستخلص: Purpose: To evaluate the antineoplastic therapy (AT) as a risk factor for dental caries lesions independent of other risk factors such as income, family education, stimulated salivary flow rate, hygiene habits, frequency of sugar intake, and microbiota in childhood cancer (CC) patients.
Methods: 72 individuals were divided into CC patients (n=36) and healthy individuals (control group - CT n=36). Demographic data, hygiene habits, frequency of sugar intake, CC type, and AT were collected. Stimulated salivary flow rate was measured and the presence and concentration of Streptococcus mutans were assessed using a real-time polymerase chain reaction (qPCR) technique. Clinical evaluations included plaque index (PI) and decayed-missing-filled-teeth index (dmft/DMFT). Descriptive statistics, T-test, Mann-Whitney test, chi-square test, Fisher's exact test, and two-way analysis of variance were used for data analysis (p<0.05).
Results: At the time of oral evaluation, both groups exhibited similar ages with means of 12.0±3.9 years old for CC and 12.0±4.0 years old for CT patients. All CC patients underwent chemotherapy with nine also undergoing radiotherapy. Significant differences were observed between the groups in terms of color/race, income, family education, and hygiene habits. However, no statistically significant differences were found between groups regarding the frequency of sugar intake, stimulated salivary flow rate, or the concentration of Streptococcus mutans (qPCR technique). For clinical parameters, the DMF (CC:1.80, CT: 0.75), decayed (CC: 0.88, CT: 0.19), missing (CC: 0.25, CT:0), and PI (CC: 30.5%, CT: 22.6%) were higher in the CC group (p<0.05).
Conclusion: Childhood cancer (CC) patients undergoing antineoplastic therapy (AT) exhibit a higher prevalence of dental caries, regardless of income/education, frequency of sugar intake, stimulated salivary flow rate, and microbiota.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Antineoplastic protocols; Cancer survivors; Dental caries; Oral health
المشرفين على المادة: 0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20240429 Date Completed: 20240429 Latest Revision: 20240513
رمز التحديث: 20240513
DOI: 10.1007/s00520-024-08523-1
PMID: 38684520
قاعدة البيانات: MEDLINE
الوصف
تدمد:1433-7339
DOI:10.1007/s00520-024-08523-1