دورية أكاديمية
The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsia†.
| العنوان: | The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsia†. |
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| المؤلفون: | Myhrer DM; Faculty of Medicine, University of Oslo, Oslo, Norway., Frøystad M; Faculty of Medicine, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Paasche Roland MC; Department of Obstetrics, Oslo University Hospital, Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway., Ueland T; Faculty of Medicine, University of Oslo, Oslo, Norway.; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway., Lekva T; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway. |
| المصدر: | Biology of reproduction [Biol Reprod] 2024 Aug 15; Vol. 111 (2), pp. 427-435. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Champaign, Ill. : Society for the Study of Reproduction |
| مواضيع طبية MeSH: | Pre-Eclampsia*/blood , Pre-Eclampsia*/genetics , Pre-Eclampsia*/diagnosis , Leukocytes*/metabolism , RNA, Long Noncoding*/blood , RNA, Long Noncoding*/genetics, Humans ; Female ; Pregnancy ; Adult ; Biomarkers/blood |
| مستخلص: | Previous studies show differentially expressed long non-coding RNA present in the placenta from women with pre-eclampsia, potentially playing a vital role in the pathogenesis of the complication. In a published microarray study, Ribonuclease P RNA component H1 was decreased in leukocytes from women that later developed pre-eclampsia. We hypothesized that Ribonuclease P RNA component H1 decreased during pregnancy in women developing pre-eclampsia and important for the development of the complication. We isolated RNA from extracellular vesicles, leukocytes and plasma using blood samples taken at weeks 22-24 and 36-38 in women who subsequently developed pre-eclampsia and from healthy pregnancy. The expression of Ribonuclease P RNA component H1 was quantified using qPCR. Expression of Ribonuclease P RNA component H1 at 22-24 weeks was further examined to investigate its discriminatory potential of subsequent pre-eclampsia and association with clinical markers. We found lower expression of Ribonuclease P RNA component H1 in leukocytes at 22-24 and 36-38 weeks amongst women who subsequent developed pre-eclampsia compared with those who did not, while increased Ribonuclease P RNA component H1 expression was found in plasma at 36-38 weeks. Pre-eclampsia risk factors could not account for this difference in the Ribonuclease P RNA component H1 expression. Prediction of pre-eclampsia at 22-24 weeks using Ribonuclease P RNA component H1 expression in leukocytes in addition to the screening algorithm used today had a significantly better performance. In conclusion, Ribonuclease P RNA component H1 expression in leukocytes was significantly decreased in women with pre-eclampsia, and the expression at 22-24 weeks associated with the subsequent development of pre-eclampsia. Ribonuclease P RNA component H1 in leukocytes may be a useful biomarker for prediction and/or early detection of pre-eclampsia and an unknown regulator of the signaling affecting immune cells. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for the Study of Reproduction.) |
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| معلومات مُعتمدة: | 2023099 South-Eastern Norway Regional Health Authority |
| فهرسة مساهمة: | Keywords: RPPH1; lncRNA; pre-eclampsia |
| المشرفين على المادة: | 0 (RNA, Long Noncoding) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240430 Date Completed: 20240816 Latest Revision: 20240820 |
| رمز التحديث: | 20240820 |
| مُعرف محوري في PubMed: | PMC11327315 |
| DOI: | 10.1093/biolre/ioae069 |
| PMID: | 38685609 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-7268 |
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| DOI: | 10.1093/biolre/ioae069 |