دورية أكاديمية
Hydralazine use can be associated with IgM-dominated immune complex-mediated glomerulonephritis.
| العنوان: | Hydralazine use can be associated with IgM-dominated immune complex-mediated glomerulonephritis. |
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| المؤلفون: | Zhang PL; Department of Pathology, Corewell Health (East), Royal Oak, MI, USA., Metcalf BD; Department of Pathology, Corewell Health (East), Royal Oak, MI, USA., Khan S; Department of Pathology, Corewell Health (East), Royal Oak, MI, USA., Abukhaled J; Division of Nephrology, Corewell Health (East), Royal Oak, MI, USA., Zafar K; Division of Nephrology, Corewell Health (East), Royal Oak, MI, USA., Li W; Department of Pathology, Corewell Health (East), Royal Oak, MI, USA., Kanaan HD; Department of Pathology, Corewell Health (East), Royal Oak, MI, USA. |
| المصدر: | Ultrastructural pathology [Ultrastruct Pathol] 2024 Jul 03; Vol. 48 (4), pp. 317-322. Date of Electronic Publication: 2024 Apr 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8002867 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0758 (Electronic) Linking ISSN: 01913123 NLM ISO Abbreviation: Ultrastruct Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [New York] McGraw-Hill. |
| مواضيع طبية MeSH: | Hydralazine*/adverse effects , Immunoglobulin M*, Humans ; Middle Aged ; Female ; Male ; Aged, 80 and over ; Aged ; Glomerulonephritis, Membranoproliferative/immunology ; Glomerulonephritis, Membranoproliferative/pathology ; Glomerulonephritis, Membranoproliferative/chemically induced ; Antihypertensive Agents/adverse effects ; Glomerulonephritis/immunology ; Glomerulonephritis/chemically induced ; Glomerulonephritis/pathology ; Antigen-Antibody Complex |
| مستخلص: | Context: IgM-dominant immune complex-mediated glomerulonephritis (IgM-dominant ICMGN) is a rare renal entity, characterized by a membranoproliferative pattern by light microscopy, dominant IgM staining by immunofluorescent staining, and subendothelial deposits by electron microscopy. This study was to investigate if some of IgM-ICMGN were associated with autoimmune disorders induced by hydralazine. Design: Seven IgM-dominant ICMGN cases were identified over 8 years. Their pathologic phenotypes and clinical scenarios were analyzed in detail. Results: Patients' ages ranged from 47 to 87 years old with 5 women and two men. Six of seven patients had drug-induced autoimmune phenomenon (hydralazine-induced positive ANCA and ANA). All of them had renal dysfunction and some proteinuria. Most pathologic features showed a membranoproliferative pattern of glomerulonephritis with dominant IgM deposits at subendothelial spaces. IgM nephropathy (a variant of focal segmental glomerulosclerosis), chronic thrombotic microangiopathy, and cryoglobulinemic glomerulopathy were ruled out in the cases. Conclusion: The hydralazine-induced autoimmune phenomenon can be seen in IgM-dominant ICMGN, which should be classified as a subtype of membranoproliferative glomerulonephritis. |
| فهرسة مساهمة: | Keywords: Autoimmune disorder; IgM dominant glomerulopathy; hydralazine; immune complex deposits |
| المشرفين على المادة: | 26NAK24LS8 (Hydralazine) 0 (Immunoglobulin M) 0 (Antihypertensive Agents) 0 (Antigen-Antibody Complex) |
| تواريخ الأحداث: | Date Created: 20240430 Date Completed: 20240701 Latest Revision: 20240701 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1080/01913123.2024.2346660 |
| PMID: | 38685716 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1521-0758 |
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| DOI: | 10.1080/01913123.2024.2346660 |