دورية أكاديمية
أعرض في EDS

Air pollution, lung function and mortality: survival and mediation analyses in UK Biobank.

التفاصيل البيبلوغرافية
العنوان: Air pollution, lung function and mortality: survival and mediation analyses in UK Biobank.
المؤلفون: Guyatt AL; Department of Population Health Sciences, University of Leicester, Leicester, UK.; These authors are joint first authors., Cai YS; Department of Population Health Sciences, University of Leicester, Leicester, UK.; Centre for Environmental Health and Sustainability, University of Leicester, Leicester, UK.; National Institute for Health and Care Research Health Protection Research Unit in Environmental Exposures and Health, University of Leicester, Leicester, UK.; National Institute for Health and Care Research Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Research & Innovation, Leicester General Hospital, Leicester, UK.; These authors are joint first authors., Doiron D; Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University, Montréal, QC, Canada., Tobin MD; Department of Population Health Sciences, University of Leicester, Leicester, UK.; National Institute for Health and Care Research Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Research & Innovation, Leicester General Hospital, Leicester, UK., Hansell AL; Department of Population Health Sciences, University of Leicester, Leicester, UK.; Centre for Environmental Health and Sustainability, University of Leicester, Leicester, UK.; National Institute for Health and Care Research Health Protection Research Unit in Environmental Exposures and Health, University of Leicester, Leicester, UK.; National Institute for Health and Care Research Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Research & Innovation, Leicester General Hospital, Leicester, UK.
المصدر: ERJ open research [ERJ Open Res] 2024 Apr 29; Vol. 10 (2). Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 101671641 Publication Model: eCollection Cited Medium: Print ISSN: 2312-0541 (Print) Linking ISSN: 23120541 NLM ISO Abbreviation: ERJ Open Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Sheffield : European Respiratory Society, [2015]-
مستخلص: Background: Air pollution is associated with lower lung function, and both are associated with premature mortality and cardiovascular disease (CVD). Evidence remains scarce on the potential mediating effect of impaired lung function on the association between air pollution and mortality or CVD.
Methods: We used data from UK Biobank (n∼200 000 individuals) with 8-year follow-up to mortality and incident CVD. Exposures to particulate matter <10 µm (PM 10 ), particulate matter <2.5 µm (PM 2.5 ) and nitrogen dioxide (NO 2 ) were assessed by land-use regression modelling. Lung function (forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC) and the FEV 1 /FVC ratio) was measured between 2006 and 2010 and transformed to Global Lung Function Initiative (GLI) z-scores. Adjusted Cox proportional hazards and causal proportional hazards mediation analysis models were fitted, stratified by smoking status.
Results: Lower FEV 1 and FVC were associated with all-cause and CVD mortality, and incident CVD, with larger estimates in ever- than never-smokers (all-cause mortality hazard ratio per FEV 1 GLI z-score decrease 1.29 (95% CI 1.24-1.34) for ever-smokers and 1.16 (95% CI 1.12-1.21) for never-smokers). Long-term exposure to PM 2.5 or NO 2 was associated with incident CVD, with similar effect sizes for ever- and never-smokers. Mediated proportions of the air pollution-all-cause mortality estimates driven by FEV 1 were 18% (95% CI 2-33%) for PM 2.5 and 27% (95% CI 3-51%) for NO 2 . Corresponding mediated proportions for incident CVD were 9% (95% CI 4-13%) for PM 2.5 and 16% (95% CI 6-25%) for NO 2 .
Conclusions: Lung function may mediate a modest proportion of associations between air pollution and mortality and CVD outcomes. Results likely reflect the extent of either shared mechanisms or direct effects relating to lower lung function caused by air pollution.
Competing Interests: Conflict of interest: M.D. Tobin has a research collaboration with GSK, and M.D. Tobin and A.L. Guyatt have a research collaboration with Orion Pharma, all unrelated to this paper. The remaining authors have no potential conflicts of interest to disclose.
(Copyright ©The authors 2024.)
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust
تواريخ الأحداث: Date Created: 20240430 Latest Revision: 20240505
رمز التحديث: 20240505
مُعرف محوري في PubMed: PMC11057504
DOI: 10.1183/23120541.00093-2024
PMID: 38686181
قاعدة البيانات: MEDLINE
الوصف
تدمد:2312-0541
DOI:10.1183/23120541.00093-2024