دورية أكاديمية
Striatal Functional Hypoconnectivity in Patients With Schizophrenia Suffering From Negative Symptoms, Longitudinal Findings.
| العنوان: | Striatal Functional Hypoconnectivity in Patients With Schizophrenia Suffering From Negative Symptoms, Longitudinal Findings. |
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| المؤلفون: | Geffen T; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center (NCRC), Campus Mitte, Berlin, Germany., Hardikar S; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Smallwood J; Department of Psychology, Queen's University, Kingston, ON, Canada., Kaliuzhna M; Clinical and Experimental Psychopathology Laboratory, University of Geneva, Faculty of Medicine, Geneva, Switzerland., Carruzzo F; Clinical and Experimental Psychopathology Laboratory, University of Geneva, Faculty of Medicine, Geneva, Switzerland., Böge K; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.; German Center for Mental Health (DZPG), Partner Site, Berlin, Germany., Zierhut MM; Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.; German Center for Mental Health (DZPG), Partner Site, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Clinician Scientist Program, Berlin, Germany., Gutwinski S; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center (NCRC), Campus Mitte, Berlin, Germany., Katthagen T; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center (NCRC), Campus Mitte, Berlin, Germany., Kaiser S; Adult Psychiatry Division, Department of Psychiatry, Geneva University Hospital, Geneva, Switzerland., Schlagenhauf F; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center (NCRC), Campus Mitte, Berlin, Germany.; Bernstein Center for Computational Neuroscience, Berlin, Germany. |
| المصدر: | Schizophrenia bulletin [Schizophr Bull] 2024 Apr 30. Date of Electronic Publication: 2024 Apr 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0236760 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-1701 (Electronic) Linking ISSN: 05867614 NLM ISO Abbreviation: Schizophr Bull Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Cary, NC : Oxford University Press Original Publication: [Chevy Chase, Md., For sale by the Supt. of Docs., U. S. Govt. Print. Off. Washington] |
| مستخلص: | Background: Negative symptoms in schizophrenia (SZ), such as apathy and diminished expression, have limited treatments and significantly impact daily life. Our study focuses on the functional division of the striatum: limbic-motivation and reward, associative-cognition, and sensorimotor-sensory and motor processing, aiming to identify potential biomarkers for negative symptoms. Study Design: This longitudinal, 2-center resting-state-fMRI (rsfMRI) study examines striatal seeds-to-whole-brain functional connectivity. We examined connectivity aberrations in patients with schizophrenia (PwSZ), focusing on stable group differences across 2-time points using intra-class-correlation and associated these with negative symptoms and measures of cognition. Additionally, in PwSZ, we used negative symptoms to predict striatal connectivity aberrations at the baseline and used the striatal aberration to predict symptoms 9 months later. Study Results: A total of 143 participants (77 PwSZ, 66 controls) from 2 centers (Berlin/Geneva) participated. We found sensorimotor-striatum and associative-striatum hypoconnectivity. We identified 4 stable hypoconnectivity findings over 3 months, revealing striatal-fronto-parietal-cerebellar hypoconnectivity in PwSZ. From those findings, we found hypoconnectivity in the bilateral associative striatum with the bilateral paracingulate-gyrus and the anterior cingulate cortex in PwSZ. Additionally, hypoconnectivity between the associative striatum and the superior frontal gyrus was associated with lower cognition scores in PwSZ, and weaker sensorimotor striatum connectivity with the superior parietal lobule correlated negatively with diminished expression and could predict symptom severity 9 months later. Conclusions: Importantly, patterns of weaker sensorimotor striatum and superior parietal lobule connectivity fulfilled the biomarker criteria: clinical significance, reflecting underlying pathophysiology, and stability across time and centers. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| معلومات مُعتمدة: | 10001CL_169783 National Science Foundation; SCHL 1969-3/1 German Research Foundation; SCHL 1969-4/1-5/1 Heisenberg Program |
| فهرسة مساهمة: | Keywords: negative-symptoms; resting-state-functional-connectivity; rsfMRI; schizophrenia; striatum |
| تواريخ الأحداث: | Date Created: 20240430 Latest Revision: 20240430 |
| رمز التحديث: | 20240501 |
| DOI: | 10.1093/schbul/sbae052 |
| PMID: | 38687874 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1745-1701 |
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| DOI: | 10.1093/schbul/sbae052 |