دورية أكاديمية
Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer.
| العنوان: | Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer. |
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| المؤلفون: | Wang J; College of Biomedical Engineering, Sichuan University, Chengdu 610065, Sichuan, China., Li B; State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China., Cooper RC; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, United States., Huang D; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, Fujian, China.; Linda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States., Yang H; Linda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States. |
| المصدر: | Biomacromolecules [Biomacromolecules] 2024 May 13; Vol. 25 (5), pp. 2770-2779. Date of Electronic Publication: 2024 Apr 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c2000- |
| مواضيع طبية MeSH: | Disulfiram*/pharmacology , Disulfiram*/chemistry , Disulfiram*/administration & dosage , Copper*/chemistry , Copper*/pharmacology , Head and Neck Neoplasms*/drug therapy , Head and Neck Neoplasms*/pathology , Delayed-Action Preparations*/chemistry , Delayed-Action Preparations*/pharmacology, Animals ; Mice ; Humans ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/administration & dosage ; Xenograft Model Antitumor Assays ; Mice, Nude |
| مستخلص: | Drug repurposing uses approved drugs as candidate anticancer therapeutics, harnesses previous research and development efforts, and benefits from available clinically suitable formulations and evidence of patient tolerability. In this work, the drug used clinically to treat chronic alcoholism, disulfiram (DSF), was studied for its antitumor efficacy in a copper-dependent manner. The combination of DSF and copper could achieve a tumor cell growth inhibition effect comparable to those of 5-fluorouracil and taxol on head and neck cancer cells. Both bulk dendrimer hydrogel and microsized dendrimer hydrogel particles were utilized for the localized sustained release of copper in the tumor site. The localized sustained release of copper facilitated the tumor inhibition effect following intratumoral injection in a mouse's head and neck cancer model. |
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| معلومات مُعتمدة: | R01 EY024072 United States EY NEI NIH HHS |
| المشرفين على المادة: | TR3MLJ1UAI (Disulfiram) 789U1901C5 (Copper) 0 (Delayed-Action Preparations) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20240430 Date Completed: 20240513 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| مُعرف محوري في PubMed: | PMC11143945 |
| DOI: | 10.1021/acs.biomac.3c01420 |
| PMID: | 38687975 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1526-4602 |
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| DOI: | 10.1021/acs.biomac.3c01420 |