دورية أكاديمية
أعرض في EDS

Gray matter volume in women with the BRCA mutation with and without ovarian removal: evidence for increased risk of late-life Alzheimer's disease or dementia.

التفاصيل البيبلوغرافية
العنوان: Gray matter volume in women with the BRCA mutation with and without ovarian removal: evidence for increased risk of late-life Alzheimer's disease or dementia.
المؤلفون: Witt ST, Brown A; Psychology, University of Toronto, Toronto, ON, Canada., Gravelsins L; Psychology, University of Toronto, Toronto, ON, Canada., Engström M, Classon E; Department of Acute Internal Medicine and Geriatrics, and Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine, Linköping University, Linköping, Sweden., Lykke N; Thematic Studies, Linköping University, Sweden., Åvall-Lundqvist E; Department of Oncology in Linköping and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Theodorsson E; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden., Ernerudh J; Department of Clinical Immunology and Transfusion Medicine, and Department of Biomedical and Clinical Sciences, Linköping University, Sweden., Kjölhede P; Department of Obstetrics and Gynecology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Einstein G
المصدر: Menopause (New York, N.Y.) [Menopause] 2024 Jul 01; Vol. 31 (7), pp. 608-616. Date of Electronic Publication: 2024 Apr 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott-Raven Publishers Country of Publication: United States NLM ID: 9433353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0374 (Electronic) Linking ISSN: 10723714 NLM ISO Abbreviation: Menopause Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott-Raven Publishers
Original Publication: New York, NY : Raven Press, c1994-
مواضيع طبية MeSH: Alzheimer Disease*/genetics , Gray Matter*/pathology , Gray Matter*/diagnostic imaging , Magnetic Resonance Imaging* , Mutation* , Dementia*/genetics, Humans ; Female ; Middle Aged ; Cross-Sectional Studies ; Ovariectomy/adverse effects ; Aged ; Salpingo-oophorectomy ; Estradiol/blood ; Genes, BRCA1 ; Estrogen Replacement Therapy ; Genes, BRCA2 ; Menopause ; Breast Neoplasms/genetics ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Risk Factors
مستخلص: Objective: Ovarian removal prior to spontaneous/natural menopause (SM) is associated with increased risk of late life dementias including Alzheimer's disease. This increased risk may be related to the sudden and early loss of endogenous estradiol. Women with breast cancer gene mutations (BRCAm) are counseled to undergo oophorectomy prior to SM to significantly reduce their risk of developing breast, ovarian, and cervical cancers. There is limited evidence of the neurological effects of ovarian removal prior to the age of SM showing women without the BRCAm had cortical thinning in medial temporal lobe structures. A second study in women with BRCAm and bilateral salpingo-oophorectomy (BSO) noted changes in cognition.
Methods: The present, cross-sectional study examined whole-brain differences in gray matter (GM) volume using high-resolution, quantitative magnetic resonance imaging in women with BRCAm and intact ovaries (BRCA-preBSO [study cohort with BRCA mutation prior to oophorectomy]; n = 9) and after surgery with (BSO + estradiol-based therapy [ERT]; n = 10) and without (BSO; n = 10) postsurgical estradiol hormone therapy compared with age-matched women (age-matched controls; n = 10) with their ovaries.
Results: The BRCA-preBSO and BSO groups showed significantly lower GM volume in the left medial temporal and frontal lobe structures. BSO + ERT exhibited few areas of lower GM volume compared with age-matched controls. Novel to this study, we also observed that all three BRCAm groups exhibited significantly higher GM volume compared with age-matched controls, suggesting continued plasticity.
Conclusions: The present study provides evidence, through lower GM volume, to support both the possibility that the BRCAm, alone, and early life BSO may play a role in increasing the risk for late-life dementia. At least for BRCAm with BSO, postsurgical ERT seems to ameliorate GM losses.
Competing Interests: Financial disclosure/conflicts of interest: None reported.
(Copyright © 2024 by The Menopause Society.)
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المشرفين على المادة: 4TI98Z838E (Estradiol)
تواريخ الأحداث: Date Created: 20240430 Date Completed: 20240628 Latest Revision: 20240703
رمز التحديث: 20240704
DOI: 10.1097/GME.0000000000002361
PMID: 38688467
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-0374
DOI:10.1097/GME.0000000000002361