دورية أكاديمية
أعرض في EDS

Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence Markers.

التفاصيل البيبلوغرافية
العنوان: Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence Markers.
المؤلفون: Suvakov S; Division of Nephrology and Hypertension (S.S., S.P., M.J., A.K., V.D.G.), Mayo Clinic College of Medicine and Science, Rochester, MN.; Department of Physiology and Biomedical Engineering (S.S., M.J.), Mayo Clinic College of Medicine and Science, Rochester, MN., Vaughan LE; Department of Quantitative Health Sciences (L.E.V., A.M.C., S.J.B.), Mayo Clinic College of Medicine and Science, Rochester, MN., Parashuram S; Division of Nephrology and Hypertension (S.S., S.P., M.J., A.K., V.D.G.), Mayo Clinic College of Medicine and Science, Rochester, MN., Butler Tobah YS; Department of Obstetrics and Gynecology (Y.S.B.T., V.D.G.), Mayo Clinic College of Medicine and Science, Rochester, MN., Jayachandran M; Division of Nephrology and Hypertension (S.S., S.P., M.J., A.K., V.D.G.), Mayo Clinic College of Medicine and Science, Rochester, MN.; Department of Physiology and Biomedical Engineering (S.S., M.J.), Mayo Clinic College of Medicine and Science, Rochester, MN.; Division of Hematology (M.J.), Mayo Clinic College of Medicine and Science, Rochester, MN., Kattah A; Division of Nephrology and Hypertension (S.S., S.P., M.J., A.K., V.D.G.), Mayo Clinic College of Medicine and Science, Rochester, MN., Chamberlain AM; Department of Quantitative Health Sciences (L.E.V., A.M.C., S.J.B.), Mayo Clinic College of Medicine and Science, Rochester, MN.; Department of Cardiovascular Medicine (A.M.C.), University of Belgrade, Serbia., Bielinski SJ; Department of Quantitative Health Sciences (L.E.V., A.M.C., S.J.B.), Mayo Clinic College of Medicine and Science, Rochester, MN., Milic N; Department of Medical Statistics and Informatics, Medical Faculty (N.M.), University of Belgrade, Serbia., Garovic VD; Division of Nephrology and Hypertension (S.S., S.P., M.J., A.K., V.D.G.), Mayo Clinic College of Medicine and Science, Rochester, MN.; Department of Obstetrics and Gynecology (Y.S.B.T., V.D.G.), Mayo Clinic College of Medicine and Science, Rochester, MN.
المصدر: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Jul; Vol. 81 (7), pp. 1550-1560. Date of Electronic Publication: 2024 May 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
أسماء مطبوعة: Publication: : Hagerstown, MD : Lippincott, Williams & Wilkins
Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]-
مواضيع طبية MeSH: Pre-Eclampsia*/epidemiology , Pre-Eclampsia*/diagnosis , Biomarkers*/blood , Biomarkers*/urine , Cellular Senescence*/physiology, Humans ; Female ; Pregnancy ; Adult ; Aging ; Klotho Proteins ; Aging, Premature/epidemiology ; Leptin/blood ; Prospective Studies ; Adiponectin/blood ; Glucuronidase/blood
مستخلص: Background: Senescence, a mechanism of cellular aging, which is characterized by irreversible proliferation arrest and a proinflammatory secretory phenotype, has been documented in women with preeclampsia. As cellular senescence can persist and progress, we postulated that it is associated with accelerated aging phenotype and accumulation of comorbidities in women with a history of preeclampsia.
Methods: We included a cohort of women with a history of preeclampsia (n=40) age- and parity-matched to a group of referent women with normotensive pregnancies (n=40). Women with prior major cardiovascular events, neurological, or autoimmune conditions were excluded. We collected urine and blood samples to study markers of aging, data on multimorbidity at the time of enrollment, and prospectively followed them for events over the course of 6 years, on average.
Results: Women with a history of preeclampsia exhibited unfavorable aging profiles compared with referent women, including decreased urinary α-Klotho ( P =0.018); increased leptin ( P =0.016) and leptin/adiponectin ratio ( P =0.027), and increased extracellular vesicles positive for tissue factor ( P =0.025). Women with a history of preeclampsia likewise had a higher rate of comorbidities at the time of enrollment ( P =0.003) and had a 4× higher risk of developing major cardiovascular events compared with referent women ( P =0.003).
Conclusions: Our data suggest that a history of preeclampsia is associated with accelerated aging as indicated by senescence marker differences and the accumulation of multimorbidity later in life. Targeting cellular senescence may offer novel, mechanism-based approaches for the diagnosis and treatment of adverse health outcomes in women with a history of preeclampsia.
Competing Interests: Disclosures None.
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معلومات مُعتمدة: R01 HL136348 United States HL NHLBI NIH HHS; R33 AG058738 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: aging; cardiovascular diseases; high blood pressure; hypertension; preeclampsia; pregnancy
المشرفين على المادة: 0 (Biomarkers)
EC 3.2.1.31 (Klotho Proteins)
0 (Leptin)
0 (Adiponectin)
EC 3.2.1.31 (Glucuronidase)
تواريخ الأحداث: Date Created: 20240501 Date Completed: 20240612 Latest Revision: 20240614
رمز التحديث: 20240614
مُعرف محوري في PubMed: PMC11168873
DOI: 10.1161/HYPERTENSIONAHA.123.22250
PMID: 38690656
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4563
DOI:10.1161/HYPERTENSIONAHA.123.22250