التفاصيل البيبلوغرافية
| العنوان: |
Protective effect of provitamin A dietary carotenoid intake on overweight/obesity and their relation to inflammatory and oxidative stress biomarkers - a case-control study. |
| المؤلفون: |
Koós N; Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. Torsten.Bohn@lih.lu., Vahid F; Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. Torsten.Bohn@lih.lu., Bohn T; Nutrition and Health Research Group, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg. Torsten.Bohn@lih.lu. |
| المصدر: |
Food & function [Food Funct] 2024 May 20; Vol. 15 (10), pp. 5510-5526. Date of Electronic Publication: 2024 May 20. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: |
Carotenoids*/administration & dosage , Oxidative Stress*/drug effects , Biomarkers*/blood , Obesity* , Overweight* , Inflammation*/blood, Humans ; Female ; Male ; Middle Aged ; Case-Control Studies ; Adult ; Vitamin A/administration & dosage ; Vitamin A/blood ; Provitamins/administration & dosage ; beta Carotene/administration & dosage ; Vegetables/chemistry ; Diet ; Fruit ; Xanthophylls/administration & dosage ; Xanthophylls/pharmacology ; Beta-Cryptoxanthin/administration & dosage ; Interleukin-6/blood ; Tumor Necrosis Factor-alpha/blood ; Interleukin-1beta/blood |
| مستخلص: |
This investigation assessed associations between dietary carotenoid intake and the odds of overweight/obesity, as well as inflammatory/oxidative stress biomarkers, in 851 participants with overweight/obesity (BMI ≥25 kg m -2 ) and 754 normal-weight controls. A 124-item food-frequency-questionnaire (FFQ) and food composition databases were employed to estimate carotenoid intake. Binary logistic regressions assessed the association of carotenoid intake with the odds of overweight/obesity, adjusting for several potential confounders. Multiple linear regression models revealed associations between carotenoid intake and biomarkers (anthropometrics, blood lipids, inflammation, antioxidant status). Logistic regression models adjusted for various confounders and fruits and vegetables showed protective associations for provitamin A carotenoids ( i.e. , β-carotene + α-carotene + β-cryptoxanthin; odds ratio (OR): 0.655, p = 0.041) and astaxanthin (OR: 0.859, p = 0.017). Similarly adjusted multiple linear regressions revealed significant associations between several carotenoids and lower levels of interleukin (IL)-6, IL-1β, and TNF-α and increased IL-10 and total antioxidant capacity. Further analysis revealed that lycopene was significantly associated with increased odds of overweight/obesity (OR: 1.595, p = 0.032) in a model adjusted for various confounders and vegetables ( i.e. , unadjusted for fruits). A protective association between the sum of provitamin A carotenoid and astaxanthin dietary intake and the odds of having overweight/obesity was found. The findings that carotenoids other than lycopene were not or inversely associated with the odds of overweight/obesity may point toward differentiating effects of various carotenoids or their associations with different food groups. Provitamin A rich food items including fruits and vegetables appear to be a prudent strategy to reduce inflammation and the odds of having overweight/obesity. |
| المشرفين على المادة: |
0 (alpha-carotene) |
| تواريخ الأحداث: |
Date Created: 20240501 Date Completed: 20240520 Latest Revision: 20240520 |
| رمز التحديث: |
20240520 |
| DOI: |
10.1039/d3fo05648a |
| PMID: |
38690968 |
| قاعدة البيانات: |
MEDLINE |
