دورية أكاديمية
Omentin-1 May Be One Treatment Factor for Intravenous Thrombolysis of Acute Cerebral Infarction Through the Inhibition of NLRP3 Ubiquitination by AMPK Function: Preliminary Findings.
| العنوان: | Omentin-1 May Be One Treatment Factor for Intravenous Thrombolysis of Acute Cerebral Infarction Through the Inhibition of NLRP3 Ubiquitination by AMPK Function: Preliminary Findings. |
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| المؤلفون: | Xu J; Department of Emergency, Shanghai Jiading District, Nanxiang Hospital, Shanghai, China., Huang S; Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai, China. |
| المصدر: | Neurology India [Neurol India] 2024 Mar 01; Vol. 72 (2), pp. 309-318. Date of Electronic Publication: 2024 Apr 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 0042005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1998-4022 (Electronic) Linking ISSN: 00283886 NLM ISO Abbreviation: Neurol India Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mumbai : Medknow Publications Original Publication: Bombay : Neurological Society of India |
| مواضيع طبية MeSH: | Cytokines*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , GPI-Linked Proteins*/metabolism , Lectins* , Ubiquitination*/drug effects , Mice, Inbred C57BL*, Animals ; Male ; Mice ; Humans ; Disease Models, Animal ; Cerebral Infarction/drug therapy ; AMP-Activated Protein Kinases/metabolism ; Thrombolytic Therapy/methods ; Middle Aged ; Aged |
| مستخلص: | Background: Acute cerebral infarction (ACI) is a common neurological disease that is associated with high morbidity, disability and mortality rates. At present, antiplatelet therapy is a necessary treatment for ACI. The present study aimed to investigate the effects of omentin-1 on the intravenous thrombolysis of ACI. Objective: The present study aimed to investigate the effects of omentin-1 on the intravenous thrombolysis of ACI. Material and Methods: The mouse model of ACI was induced using male C57BL/6 mice through middle cerebral artery occlusion (MCAO). Meanwhile, the murine BV2 microglial cells were pretreated with 0.1 mg/ml of lipopolysaccharide (LPS), and then induced with 2 mM of adenosine triphosphate (ATP). Results: The omentin-1 mRNA expression in patients receiving intravenous thrombolysis for ACI was down-regulated compared with the normal group. Additionally, the serum level of omentin-1 was negatively correlated with National Institute of Health Stroke Scale (NIHSS) score or serum level of IL-1β or MMP-2 in patients receiving intravenous thrombolysis for ACI. Meanwhile, the serum mRNA expression of omentin-1 was positively correlated with Barthel index or high-sensitivity C-reactive protein (hs-CRP) in patients undergoing intravenous thrombolysis for ACI. As observed from the in vitro model, Omentin-1 reduced inflammation, promoted cell growth, alleviated ROS-induced oxidative stress, and enhanced AMPK activity through activating NLRP3 ubiquitination. Omentin-1 presented ACI in the mouse model of ACI. Regulating AMPK activity contributed to controlling the effects of Omentin-1 on the in vitro model. Conclusions: Omentin-1 reduced neuroinflammation and ROS-induced oxidative stress in the mouse model of ACI, which was achieved by inhibiting NLRP3 ubiquitination through regulating AMPK activity. Therefore, omentin-1 may serve as a treatment factor for the intravenous thrombolysis of ACI in further clinical application. (Copyright © 2024 Copyright: © 2024 Neurology India, Neurological Society of India.) |
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| المشرفين على المادة: | 0 (Cytokines) 0 (NLR Family, Pyrin Domain-Containing 3 Protein) 0 (GPI-Linked Proteins) 0 (Lectins) 0 (ITLN1 protein, human) EC 2.7.11.31 (AMP-Activated Protein Kinases) 0 (Itln1 protein, mouse) 0 (Nlrp3 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240501 Date Completed: 20240501 Latest Revision: 20240702 |
| رمز التحديث: | 20240702 |
| DOI: | 10.4103/ni.ni_1325_21 |
| PMID: | 38691475 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1998-4022 |
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| DOI: | 10.4103/ni.ni_1325_21 |