دورية أكاديمية
أعرض في EDS

Interdependence of cellular and network properties in respiratory rhythm generation.

التفاصيل البيبلوغرافية
العنوان: Interdependence of cellular and network properties in respiratory rhythm generation.
المؤلفون: Phillips RS; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101., Baertsch NA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101.; Pulmonary, Critical Care and Sleep Medicine, Department of Pediatrics, University of Washington, Seattle, WA 98195.; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 07; Vol. 121 (19), pp. e2318757121. Date of Electronic Publication: 2024 May 01.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Action Potentials*/physiology, Animals ; Models, Neurological ; Neurons/physiology ; Respiration ; Nerve Net/physiology ; Respiratory Center/physiology ; Computer Simulation ; Sodium/metabolism
مستخلص: How breathing is generated by the preBötzinger complex (preBötC) remains divided between two ideological frameworks, and a persistent sodium current (I NaP ) lies at the heart of this debate. Although I NaP is widely expressed, the pacemaker hypothesis considers it essential because it endows a small subset of neurons with intrinsic bursting or "pacemaker" activity. In contrast, burstlet theory considers I NaP dispensable because rhythm emerges from "preinspiratory" spiking activity driven by feed-forward network interactions. Using computational modeling, we find that small changes in spike shape can dissociate I NaP from intrinsic bursting. Consistent with many experimental benchmarks, conditional effects on spike shape during simulated changes in oxygenation, development, extracellular potassium, and temperature alter the prevalence of intrinsic bursting and preinspiratory spiking without altering the role of I NaP . Our results support a unifying hypothesis where I NaP and excitatory network interactions, but not intrinsic bursting or preinspiratory spiking, are critical interdependent features of preBötC rhythmogenesis.
Competing Interests: Competing interests statement:The authors declare no competing interest.
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معلومات مُعتمدة: K01 DA058543 United States DA NIDA NIH HHS; R00 HL145004 United States HL NHLBI NIH HHS; R01 HL166317 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: afterhyperpolarization; central pattern generation; respiratory control; rhythm generation; spike shape
المشرفين على المادة: 9NEZ333N27 (Sodium)
تواريخ الأحداث: Date Created: 20240501 Date Completed: 20240501 Latest Revision: 20240520
رمز التحديث: 20240520
مُعرف محوري في PubMed: PMC11087776
DOI: 10.1073/pnas.2318757121
PMID: 38691591
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.2318757121