دورية أكاديمية
Nitroxyl donating and visualization with a coumarin-based fluorescence probe.
| العنوان: | Nitroxyl donating and visualization with a coumarin-based fluorescence probe. |
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| المؤلفون: | Chen J; Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan 570228, China., Cui Y; College of Life Sciences, Nankai University, Tianjin 300071, China., Wu P; Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan 570228, China., Dassanayake R; Department of Biosystems Technology, Faculty of Technology, University of Sri Jayewardenepura, Pitipana, Homagama 10200, Sri Lanka., Yu P; Department of Joint Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China., Fu K; Department of Joint Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China., Sun Z; Beijing Engineering Research Center of Printed Electronics, Beijing Institute of Graphic Communication, Beijing 102600, China., Liu Y; Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan 570228, China., Zhou Y; Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education and School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan 570228, China. Electronic address: yzhou@hainanu.edu.cn. |
| المصدر: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Aug 05; Vol. 316, pp. 124317. Date of Electronic Publication: 2024 Apr 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Kidlington, Oxford, U.K. ; Tarrytown, NY] : Pergamon, c1994- |
| مواضيع طبية MeSH: | Coumarins*/chemistry , Fluorescent Dyes*/chemistry , Nitrogen Oxides*/chemistry , Nitrogen Oxides*/analysis, Humans ; Spectrometry, Fluorescence ; HeLa Cells |
| مستخلص: | Nitroxyl (HNO), the single-electron reduction product of nitric oxide (NO), has attracted great interest in the treatment of congestive heart failure in clinical trials. In this paper, we describe the first coumarin-based compound N-hydroxy-2-oxo-2H-chromene-6-sulfonamide (CD1) as a dualfunctional HNO donor, which can release both an HNO signaling molecule and a fluorescent reporter. Under physiological conditions (pH 7.4 and 37 °C), the CD1 HNO donor can readily decompose with a half-life of ∼90 min. The corresponding stoichiometry HNO from the CD1 donor was confirmed using both Vitamin B Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cell imaging; Donor molecule; Fluorescence; Nitroxyl (HNO); Probe |
| المشرفين على المادة: | GFQ4MMS07W (nitroxyl) 0 (Coumarins) 0 (Fluorescent Dyes) 0 (Nitrogen Oxides) A4VZ22K1WT (coumarin) |
| تواريخ الأحداث: | Date Created: 20240501 Date Completed: 20240513 Latest Revision: 20240513 |
| رمز التحديث: | 20240514 |
| DOI: | 10.1016/j.saa.2024.124317 |
| PMID: | 38692102 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3557 |
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| DOI: | 10.1016/j.saa.2024.124317 |