دورية أكاديمية
Treatment of mammary gland tumors in bitches: effects of sodium dichloroacetate as neoadjuvant therapy.
| العنوان: | Treatment of mammary gland tumors in bitches: effects of sodium dichloroacetate as neoadjuvant therapy. |
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| المؤلفون: | Kluthcovsky LC; Postgraduate Program in Animal Science, School of Life Sciences, Pontifical Catholic University of Parana (PUCPR), Curitiba, Brazil., Jennifer M; Postgraduate Program in Animal Science, School of Life Sciences, Pontifical Catholic University of Parana (PUCPR), Curitiba, Brazil., Merisio TM; Postgraduate Program in Animal Science, School of Life Sciences, Pontifical Catholic University of Parana (PUCPR), Curitiba, Brazil., Castro JLC; Postgraduate Program in Animal Science, School of Life Sciences, Pontifical Catholic University of Parana (PUCPR), Curitiba, Brazil., Filho JRE; Postgraduate Program in Animal Science, School of Life Sciences, Pontifical Catholic University of Parana (PUCPR), Curitiba, Brazil. |
| المصدر: | The Journal of veterinary medical science [J Vet Med Sci] 2024 Jun 19; Vol. 86 (6), pp. 677-683. Date of Electronic Publication: 2024 May 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Society Of Veterinary Science Country of Publication: Japan NLM ID: 9105360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-7439 (Electronic) Linking ISSN: 09167250 NLM ISO Abbreviation: J Vet Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Japanese Society Of Veterinary Science |
| مواضيع طبية MeSH: | Mammary Neoplasms, Animal*/drug therapy , Mammary Neoplasms, Animal*/surgery , Dog Diseases*/drug therapy , Dichloroacetic Acid*/therapeutic use , Neoadjuvant Therapy*/veterinary, Animals ; Dogs ; Female |
| مستخلص: | Mastectomy is the standard treatment for mammary gland tumors in dogs. In addition to traditional therapy, sodium dichloroacetate (DCA) can act as target therapy, as it may promote autophagy, reduce metastatic potential, and tumor proliferation in mammary tumor cell lines. This study aimed to analyze the effects of DCA as preoperative therapy for mammary tumors in bitches. Nineteen animals were selected, and they received DCA at a dose of 10 mg/kg orally every 12 hr, for 15 days. The periodic evaluation included hematological analysis (complete blood count and biochemical markers), evaluation of gastrointestinal adverse effects, evaluation of tumor volume, histopathological analysis, and immunohistochemical evaluation (Ki67 and cyclooxygenase-2/COX-2 markers). After treatment, there was a significant reduction in hematocrit (P=0.02) and leukocyte (P=0.04) means. Despite the variations for these two hematological parameters, the means remained within the reference range for the species. There were two cases of vomiting and one case of diarrhea. Most cases were classified as carcinoma in mixed tumor (n=7, 36.8%), followed by solid carcinoma (n=6, 31.6%). Nine cases (47.4%) showed reduced tumor volume, nine (47.4%) had stable disease, and one showed progressive disease. While there was no sample with a COX-2 score higher than 6, tumor samples with COX-2 scores 3 and 4 were significantly associated with stable disease or progression. DCA preoperative treatment for bitches with mammary gland tumors showed safety and potential cytoreduction in some cases. |
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| فهرسة مساهمة: | Keywords: dog; target therapy; veterinary oncology |
| المشرفين على المادة: | 9LSH52S3LQ (Dichloroacetic Acid) |
| تواريخ الأحداث: | Date Created: 20240501 Date Completed: 20240619 Latest Revision: 20240622 |
| رمز التحديث: | 20240622 |
| مُعرف محوري في PubMed: | PMC11187584 |
| DOI: | 10.1292/jvms.23-0393 |
| PMID: | 38692860 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1347-7439 |
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| DOI: | 10.1292/jvms.23-0393 |