دورية أكاديمية
A randomized phase III trial of postoperative surveillance for pathological stage II and IIIA non-small cell lung cancer (JCOG2012, PHOENIX).
| العنوان: | A randomized phase III trial of postoperative surveillance for pathological stage II and IIIA non-small cell lung cancer (JCOG2012, PHOENIX). |
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| المؤلفون: | Tane K; Division of Thoracic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan., Shiono S; Department of Surgery II, Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagatashi, Yamagata 990-9585, Japan., Wakabayashi M; JCOG Data Center/Operations Office, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuoku, Tokyo, 104-0045, Japan., Kataoka T; JCOG Data Center/Operations Office, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuoku, Tokyo, 104-0045, Japan., Mitome N; JCOG Data Center/Operations Office, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuoku, Tokyo, 104-0045, Japan., Fukuda H; JCOG Data Center/Operations Office, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuoku, Tokyo, 104-0045, Japan., Aokage K; Division of Thoracic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan., Watanabe SI; Division of Thoracic Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuoku, Tokyo, 104-0045, Japan. |
| مؤلفون مشاركون: | In behalf of the Lung Cancer Surgical Study Group/Japan Clinical Oncology Group |
| المصدر: | Japanese journal of clinical oncology [Jpn J Clin Oncol] 2024 Aug 14; Vol. 54 (8), pp. 926-929. |
| نوع المنشور: | Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Clinical Trial Protocol; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0313225 Publication Model: Print Cited Medium: Internet ISSN: 1465-3621 (Electronic) Linking ISSN: 03682811 NLM ISO Abbreviation: Jpn J Clin Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Oxford University Press Original Publication: Tokyo, Foundation of Clinical Oncology. |
| مواضيع طبية MeSH: | Carcinoma, Non-Small-Cell Lung*/surgery , Carcinoma, Non-Small-Cell Lung*/pathology , Lung Neoplasms*/pathology , Lung Neoplasms*/surgery , Lung Neoplasms*/diagnostic imaging , Neoplasm Staging*, Humans ; Male ; Female ; Tomography, X-Ray Computed ; Neoplasm Recurrence, Local/pathology ; Middle Aged ; Aged ; Pneumonectomy ; Adult ; Japan/epidemiology |
| مستخلص: | The goal of postoperative surveillance following non-small cell lung cancer surgery is to detect recurrence and second primary malignancies while curative treatment is still possible. Although several guidelines recommend that patients have computed tomography (CT) scans every 6 months for the first 2 years after resection, then once a year, there is no evidence that it is effective for survival, especially in locally advanced non-small cell lung cancer. In October 2022, we launched a multi-institutional, randomized controlled phase III trial for pathological stage II and IIIA non-small cell lung cancer patients to confirm the non-inferiority of less intensive surveillance with less frequent CT scans versus standard surveillance in terms of overall survival. The primary endpoint is overall survival. We intend to enroll 1100 patients from 45 institutions over 4 years. The trial has been registered in the Japan Registry of Clinical Trials under the code jRCT1030220361 (https://jrct.niph.go.jp/latest-detail/jRCT1030220361). (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | 2020-J-3 National Cancer Center Research and Development Fund; 23ck0106897h0001 Japan Agency for Medical Research and Development |
| فهرسة مساهمة: | Keywords: chest computed tomography scan; non-small cell lung cancer; surgery; surveillance |
| تواريخ الأحداث: | Date Created: 20240502 Date Completed: 20240814 Latest Revision: 20240814 |
| رمز التحديث: | 20240814 |
| DOI: | 10.1093/jjco/hyae056 |
| PMID: | 38693750 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1465-3621 |
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| DOI: | 10.1093/jjco/hyae056 |