دورية أكاديمية

Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models.

التفاصيل البيبلوغرافية
العنوان: Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models.
المؤلفون: Akhigbe RE; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria., Odetayo AF; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.; Department of Physiology, University of Ilorin, Ilorin, Kwara State, Nigeria., Akhigbe TM; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.; Breeding and Plant Genetics Unit, Department of Agronomy, Osun State University, Osun State, Nigeria., Hamed MA; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.; Department of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.; The Brainwill Laboratory, Osogbo, Osun State, Nigeria., Ashonibare PJ; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
المصدر: Heliyon [Heliyon] 2024 Apr 21; Vol. 10 (9), pp. e27760. Date of Electronic Publication: 2024 Apr 21 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Testicular torsion is a urological emergency that involves the twisting of the spermatic cord along its course. Compelling pieces of evidence have implicated oxidative stress-sensitive signaling in pathogenesis of testicular I/R injury. Although, surgical detorsion is the mainstay management; blockade of the pathways involved in the pathogenesis may improve the surgical outcome. Experimental studies using various testicular I/R models have been reported in a bid to explore the mechanisms associated with testicular I/R and evaluate the benefits of potential therapeutic measures; however, most are limited by their shortcomings. Thus, this review was intended to describe the details of the available testicular I/R models as well as their merits and drawbacks, the pathophysiological basis and consequences of testicular I/R, and the pharmacological agents that have being proposed to confer testicular benefits against testicular I/R. This provides an understanding of the pathophysiological events and available models used in studying testicular I/R. In addition, this research provides evidence-based molecules with therapeutic potentials as well as their mechanisms of action in testicular I/R.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
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فهرسة مساهمة: Keywords: Infertility; Ischemia; Reperfusion; Sperm; Testicular torsion; Testis
تواريخ الأحداث: Date Created: 20240502 Latest Revision: 20240503
رمز التحديث: 20240503
مُعرف محوري في PubMed: PMC11058307
DOI: 10.1016/j.heliyon.2024.e27760
PMID: 38694115
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2024.e27760