دورية أكاديمية
Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane.
| العنوان: | Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane. |
|---|---|
| المؤلفون: | Connors CQ; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032., Mauro MS; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032., Wiles JT; Department of Biological Sciences, Columbia University, New York, NY 10027., Countryman AD; Department of Biomedical Engineering, Columbia University, New York, NY 10027., Martin SL; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032., Lacroix B; Université Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.; Université de Montpellier, CNRS, Centre de Recherche en Biologie Cellulaire de Montpellier, UMR 5237 Montpellier, France., Shirasu-Hiza M; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032., Dumont J; Université Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France., Kasza KE; Department of Mechanical Engineering, Columbia University, New York, NY 10027., Davies TR; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032.; Department of Biosciences, Durham University, Durham DH1 3LE, UK., Canman JC; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032. |
| المصدر: | Molecular biology of the cell [Mol Biol Cell] 2024 Jul 01; Vol. 35 (7), pp. ar94. Date of Electronic Publication: 2024 May 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Cell Biology Country of Publication: United States NLM ID: 9201390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-4586 (Electronic) Linking ISSN: 10591524 NLM ISO Abbreviation: Mol Biol Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Society for Cell Biology, c1992- |
| مواضيع طبية MeSH: | Cytokinesis*/physiology , Caenorhabditis elegans*/metabolism , Caenorhabditis elegans*/embryology , Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics , Septins*/metabolism , Septins*/genetics , Cell Division* , Germ Cells*/metabolism , Germ Cells*/cytology , Actins*/metabolism, Animals ; Contractile Proteins/metabolism ; Actomyosin/metabolism |
| مستخلص: | Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of an actomyosin contractile ring at the division plane. The mechanisms underlying cell type-specific differences in cytokinesis remain unknown. Germ cells are totipotent cells that pass genetic information to the next generation. Previously, using formin cyk-1 (ts) mutant Caenorhabditis elegans 4-cell embryos, we found that the P2 germ precursor cell is protected from cytokinesis failure and can divide with greatly reduced F-actin levels at the cell division plane. Here, we identified two canonical germ fate determinants required for P2-specific cytokinetic protection: PIE-1 and POS-1. Neither has been implicated previously in cytokinesis. These germ fate determinants protect P2 cytokinesis by reducing the accumulation of septin UNC-59 and anillin ANI-1 at the division plane, which here act as negative regulators of cytokinesis. These findings may provide insight into the regulation of cytokinesis in other cell types, especially in stem cells with high potency. |
| التعليقات: | Update of: bioRxiv. 2023 Nov 17:2023.11.17.566773. doi: 10.1101/2023.11.17.566773. (PMID: 38014027) |
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| معلومات مُعتمدة: | R01 GM117407 United States GM NIGMS NIH HHS; P40 OD010440 United States OD NIH HHS; R01 AG045842 United States AG NIA NIH HHS; R35 GM138380 United States GM NIGMS NIH HHS; R35 GM127049 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Caenorhabditis elegans Proteins) EC 3.6.1.- (Septins) 0 (anillin) 0 (Actins) 0 (Contractile Proteins) 9013-26-7 (Actomyosin) |
| تواريخ الأحداث: | Date Created: 20240502 Date Completed: 20240606 Latest Revision: 20240714 |
| رمز التحديث: | 20240714 |
| مُعرف محوري في PubMed: | PMC11244169 |
| DOI: | 10.1091/mbc.E24-02-0096-T |
| PMID: | 38696255 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1939-4586 |
|---|---|
| DOI: | 10.1091/mbc.E24-02-0096-T |