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Optogenetic Inhibition of the Orbitofrontal Cortex Disrupts Inhibitory Control during Stop-Change Performance in Male Rats.

التفاصيل البيبلوغرافية
العنوان: Optogenetic Inhibition of the Orbitofrontal Cortex Disrupts Inhibitory Control during Stop-Change Performance in Male Rats.
المؤلفون: Brockett AT; Department of Psychology, University of Maryland, College Park, Maryland 20742 adam.brockett@unh.edu.; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, Maryland 20742.; Department of Biological Sciences, University of New Hampshire, Durham, New Hampshire 03824., Kumar N; Department of Psychology, University of Maryland, College Park, Maryland 20742., Sharalla P; Department of Psychology, University of Maryland, College Park, Maryland 20742., Roesch MR; Department of Psychology, University of Maryland, College Park, Maryland 20742.; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, Maryland 20742.
المصدر: ENeuro [eNeuro] 2024 May 15; Vol. 11 (5). Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Washington, DC] : Society for Neuroscience, [2014]-
مواضيع طبية MeSH: Optogenetics* , Prefrontal Cortex*/physiology , Rats, Long-Evans* , Neurons*/physiology , Halorhodopsins*/metabolism, Animals ; Male ; Inhibition, Psychological ; Reaction Time/physiology ; Rats ; Action Potentials/physiology
مستخلص: Historically, the orbitofrontal cortex (OFC) has been implicated in a variety of behaviors ranging from reversal learning and inhibitory control to more complex representations of reward value and task space. While modern interpretations of the OFC's function have focused on a role in outcome evaluation, these cognitive processes often require an organism to inhibit a maladaptive response or strategy. Single-unit recordings from the OFC in rats performing a stop-change task show that the OFC responds strongly to STOP trials. To investigate the role that the OFC plays in stop-change performance, we expressed halorhodopsin (eNpHR3.0) in excitatory neurons in the OFC and tested rats on the stop-change task. Previous work suggests that the OFC differentiates between STOP trials based on trial sequence (i.e., gS trials: STOP trials preceded by a GO vs sS trials: STOP trials preceded by a STOP). We found that yellow light activation of the eNpHR3.0-expressing neurons significantly decreased accuracy only on STOP trials that followed GO trials (gS trials). Further, optogenetic inhibition of the OFC speeded reaction times on error trials. This suggests that the OFC plays a role in inhibitory control processes and that this role needs to be accounted for in modern interpretations of OFC function.
Competing Interests: The authors declare no competing financial interests.
(Copyright © 2024 Brockett et al.)
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معلومات مُعتمدة: R01 DA031695 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: OFC; inhibitory control; optogenetics; response inhibition; stop-signal
تواريخ الأحداث: Date Created: 20240502 Date Completed: 20240515 Latest Revision: 20240518
رمز التحديث: 20240518
مُعرف محوري في PubMed: PMC11097625
DOI: 10.1523/ENEURO.0015-24.2024
PMID: 38697842
قاعدة البيانات: MEDLINE
الوصف
تدمد:2373-2822
DOI:10.1523/ENEURO.0015-24.2024