دورية أكاديمية
Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia.
| العنوان: | Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia. |
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| المؤلفون: | Xiang C; Institute of Diabetes, Southeast University, Nanjing, China.; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia., Sun Y; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia., Luo Y; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China., Xie C; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia., Huang W; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia., Jones KL; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia., Horowitz M; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia., Sun Z; Institute of Diabetes, Southeast University, Nanjing, China., Rayner CK; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia., Ma J; Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China., Wu T; Institute of Diabetes, Southeast University, Nanjing, China.; Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, Australia. |
| المصدر: | Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Aug; Vol. 26 (8), pp. 3119-3127. Date of Electronic Publication: 2024 May 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell, c1999- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/physiopathology , Diabetes Mellitus, Type 2*/blood , Diabetes Mellitus, Type 2*/metabolism , Gastric Emptying*/physiology , Postprandial Period* , Blood Glucose*/metabolism , Blood Glucose*/analysis, Humans ; Female ; Male ; Middle Aged ; Sex Factors ; Aged ; Australia/epidemiology ; Adult ; Breath Tests ; Cohort Studies ; Dietary Carbohydrates/administration & dosage ; Glucose/metabolism ; China/epidemiology ; Metformin/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Hyperglycemia |
| مستخلص: | Aim: To evaluate sex differences in gastric emptying and the glycaemic response to a glucose drink and a high carbohydrate meal in type 2 diabetes (T2D). Methods: In cohort 1, 70 newly diagnosed, treatment-naïve Chinese patients with T2D (44 men) recruited from a diabetes outpatient clinic ingested a 75-g glucose drink containing 150 mg 13 C-acetate. In cohort 2, 101 Australian patients with T2D (67 male) recruited from the community, managed by diet and/or metformin monotherapy, ingested a semi-solid mashed potato meal, labelled with 100 μl 13 C-octanoic acid. Breath samples were collected over 3 and 4 h, respectively, for assessment of gastric emptying, and venous blood was sampled for evaluation of glycaemia (with and without adjustment for each participant's estimated total blood volume). Results: Gastric emptying was slower in female than male subjects in both cohorts (both p < .01). Multiple linear regression analyses revealed that gastric emptying was independently associated with sex (both p < .05). Without adjustment for blood volume, the glycaemic responses to oral glucose and the mixed meal were greater in female subjects (both p < .001). However, after adjustment for blood volume, the glycaemic responses were greater in men (both p < .05). Conclusions: Gastric emptying is slower in women than men with T2D, associated with a reduced blood volume-adjusted glycaemic response to oral glucose and a mixed meal in women. These observations highlight the sex difference in postprandial glucose handling, which is relevant to the personalized management of postprandial glycaemia in T2D. (© 2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | 1147333 Australian National Health and Medical Research Council; KYCX22_0295 Postgraduate Research & Practice Innovation Program of Jiangsu Province |
| فهرسة مساهمة: | Keywords: gastric emptying; postprandial glycaemia; sex disparity; type 2 diabetes |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Dietary Carbohydrates) IY9XDZ35W2 (Glucose) 9100L32L2N (Metformin) 0 (Hypoglycemic Agents) |
| تواريخ الأحداث: | Date Created: 20240503 Date Completed: 20240709 Latest Revision: 20240709 |
| رمز التحديث: | 20240709 |
| DOI: | 10.1111/dom.15635 |
| PMID: | 38698649 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1463-1326 |
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| DOI: | 10.1111/dom.15635 |