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Multifunctional DNA Nanoflower Applied for High Specific Photodynamic Cancer Therapy In Vivo.

التفاصيل البيبلوغرافية
العنوان: Multifunctional DNA Nanoflower Applied for High Specific Photodynamic Cancer Therapy In Vivo.
المؤلفون: Zheng H; College of Life Sciences, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China., Feng XN; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China., Jin XW; College of Life Sciences, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China., Dai ZQ; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China., Lu S; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China., Cui YX; College of Life Sciences, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China.; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China., Kong DM; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin, China.
المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Jul 02; Vol. 25 (13), pp. e202400229. Date of Electronic Publication: 2024 Jun 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH Verlag, c2000-
مواضيع طبية MeSH: Photochemotherapy* , DNA*/chemistry , Photosensitizing Agents*/chemistry , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/chemical synthesis , Nanostructures*/chemistry, Humans ; Animals ; Mice ; Neoplasms/drug therapy ; Neoplasms/pathology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Cell Survival/drug effects ; Cell Line, Tumor
مستخلص: Photodynamic therapy (PDT) is a newly emerged strategy for disease treatment. One challenge of the application of PDT drugs is the side-effect caused by the non-specificity of the photosensitive molecules. Most of the photosensitizers may invade not only the pathogenic cells but also the normal cells. In recent, people tried to use special cargoes to deliver the drugs into target cells. DNA nanoflowers (NFs) are a kind of newly-emerged nanomaterial which constructed through DNA rolling cycle amplification (RCA) reaction. It is reported that the DNA NFs were suitable materials which have been widely applied as nanocargos for drug delivery in cancer chemotherapeutic treatment. In this paper, we have introduced a new multifunctional DNA NF which could be prepared through an one-pot RCA reaction. This proposed DNA NF contained a versatile AS1411 G-quadruplex moiety, which plays key roles not only for specific recognition of cancer cells but also for near-infrared ray based photodynamic therapy when conjugating with a special porphyrin molecule. We demonstrated that the DNA NF showed good selectivity toward cancer cells, leading to highly efficient photo-induced cytotoxicity. Moreover, the in vivo experiment results suggested this DNA NF is a promising nanomaterial for clinical PDT.
(© 2024 Wiley-VCH GmbH.)
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معلومات مُعتمدة: JCQNJC00240 Tianjin Natural Science Foundation; JCQNJC00240 Fundamental Research Funds for the Central Universities; 21874075 National Natural Science Foundation of China; 22074068 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: DNA nanoflowers; Photodynamic therapy; cancer treatment
المشرفين على المادة: 9007-49-2 (DNA)
0 (Photosensitizing Agents)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20240503 Date Completed: 20240702 Latest Revision: 20240702
رمز التحديث: 20240703
DOI: 10.1002/cbic.202400229
PMID: 38700379
قاعدة البيانات: MEDLINE
الوصف
تدمد:1439-7633
DOI:10.1002/cbic.202400229