دورية أكاديمية
Causal association between lipid-lowering drugs and cancers: A drug target Mendelian randomization study.
العنوان: | Causal association between lipid-lowering drugs and cancers: A drug target Mendelian randomization study. |
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المؤلفون: | Ding W; The Second Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, China., Chen L; Department of Gastroenterology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China., Xia J; Department of Gastroenterology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China., Pei B; The Second Clinical Medical School, Anhui University of Chinese Medicine, Hefei, Anhui, China., Song B; Department of Gastroenterology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China., Li X; Department of Gastroenterology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China. |
المصدر: | Medicine [Medicine (Baltimore)] 2024 May 03; Vol. 103 (18), pp. e38010. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
مواضيع طبية MeSH: | Mendelian Randomization Analysis* , Neoplasms*/genetics , Neoplasms*/epidemiology , Hydroxymethylglutaryl CoA Reductases*/genetics , Polymorphism, Single Nucleotide* , Proprotein Convertase 9*, Humans ; Female ; PCSK9 Inhibitors ; Hypolipidemic Agents/therapeutic use ; Male ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use |
مستخلص: | Accumulating evidences have indicated that lipid-lowering drugs have effect for the treatment of cancers. However, causal associations between lipid-lowering drugs and the risk of cancers are still unclear. In our study, we utilized single nucleotide polymorphisms of proprotein convertase subtilis kexin 9 (PCSK9) inhibitors and 3-hydroxy-3-methylglutaryl-assisted enzyme A reductase (HMGCR) inhibitors and performed a drug target Mendelian randomization to explore the causal association between lipid-lowering drugs and the risk of cancers. Five regression methods were carried out, including inverse variance weighted (IVW) method, MR Egger, weighted median, simple mode and weighted mode methods, of which IVW method was considered as the main analysis. Our outcome dataset contained the risk of breast cancer (BC), colorectal cancer, endometrial cancer, gastric cancer (GC), hepatocellular carcinoma (HCC), lung cancer, esophageal cancer, prostate cancer (PC), and skin cancer (SC). Our results demonstrated that PCSK9 inhibitors were significant associated with a decreased effect of GC [IVW: OR = 0.482, 95% CI: 0.264-0.879, P = .017]. Besides, genetic inhibitions of HMGCR were significant correlated with an increased effect of BC [IVW: OR = 1.421, 95% CI: 1.056-1.911, P = .020], PC [IVW: OR = 1.617, 95% CI: 1.234-2.120, P = .0005] and SC [IVW: OR = 1.266, 95% CI: 1.022-1.569, P = .031]. For GC [IVW: OR = 0.559, 95% CI: 0.382-0.820, P = .0029] and HCC [IVW: OR = 0.241, 95% CI: 0.085-0.686, P = .0077], HMGCR inhibitors had a protective risk. Our method suggested that PCSK9 inhibitors were significant associated with a protective effect of GC. Genetic inhibitions of HMGCR were significant correlated with an increased effect of BC, PC and SC. Meanwhile, HMGCR inhibitors had a protective risk of GC and HCC. Subsequent studies still needed to assess potential effects between lipid-lowering drugs and the risk of cancers with clinical trials. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.) |
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المشرفين على المادة: | EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases) EC 1.1.1.- (HMGCR protein, human) EC 3.4.21.- (PCSK9 protein, human) 0 (PCSK9 Inhibitors) 0 (Hypolipidemic Agents) 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) EC 3.4.21.- (Proprotein Convertase 9) |
تواريخ الأحداث: | Date Created: 20240503 Date Completed: 20240503 Latest Revision: 20240507 |
رمز التحديث: | 20240507 |
مُعرف محوري في PubMed: | PMC11062692 |
DOI: | 10.1097/MD.0000000000038010 |
PMID: | 38701318 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1536-5964 |
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DOI: | 10.1097/MD.0000000000038010 |