دورية أكاديمية
Role of genetic analysis of products of conception and PGT in managing early pregnancy loss.
| العنوان: | Role of genetic analysis of products of conception and PGT in managing early pregnancy loss. |
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| المؤلفون: | Kutteh WH; Natera, Inc., San Carlos, CA, USA.; Department of Obstetrics and Gynecology, University of Tennessee Health Sciences Center, Memphis, TN, USA.. Electronic address: wkutteh50@gmail.com., Papas RS; Department of Obstetrics and Gynecology, University of Balamand, Beirut, Lebanon., Maisenbacher MK; Natera, Inc., San Carlos, CA, USA., Dahdouh EM; ART Center, CHU Sainte-Justine, Department of Obstetrics and Gynecology, Université de Montréal, Montreal, Canada. |
| المصدر: | Reproductive biomedicine online [Reprod Biomed Online] 2024 Jul; Vol. 49 (1), pp. 103738. Date of Electronic Publication: 2023 Nov 26. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009->: Amsterdam : Elsevier Original Publication: Cambridge, UK : Reproductive Healthcare Ltd. |
| مواضيع طبية MeSH: | Preimplantation Diagnosis* , Aneuploidy* , Genetic Testing*/methods , Abortion, Habitual*/genetics, Humans ; Female ; Pregnancy ; Male ; Retrospective Studies ; Fertilization/genetics |
| مستخلص: | This article considers the addition of comprehensive 24-chromosomal microarray (CMA) analysis of products of conception (POC) to a standard evaluation for recurrent pregnancy loss (RPL) to help direct treatment towards expectant management versus IVF with preimplantation genetic testing for aneuploidies (PGT-A). The review included retrospective data from 65,333 miscarriages, a prospective evaluation of 378 couples with RPL who had CMA testing of POC and the standard workup, and data from an additional 1020 couples who were evaluated for RPL but did not undergo CMA testing of POC. Aneuploidy in POC explained the pregnancy loss in 57.7% (218/378) of cases. In contrast, the full RPL evaluation recommended by the American Society for Reproductive Medicine identified a potential cause in only 42.9% (600/1398). Combining the data from the RPL evaluation and the results of genetic testing of POC provides a probable explanation for the loss in over 90% (347/378) of women. Couples with an unexplained loss after the standard evaluation with POC aneuploidy accounted for 41% of cases; PGT-A may be considered after expectant management. Conversely, PGT-A would have a limited role in those with a euploid loss and a possible explanation after the standard workup. Categorizing a pregnancy loss as an explained versus unexplained loss after the standard evaluation combined with the results of CMA testing of POC may help identify patients who would benefit from expectant management versus PGT-A. (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aneuploidy IVF; Comprehensive chromosomal microarray; Preimplantation genetic testing; Products of conception testing; Recurrent pregnancy loss |
| تواريخ الأحداث: | Date Created: 20240503 Date Completed: 20240703 Latest Revision: 20240703 |
| رمز التحديث: | 20240704 |
| DOI: | 10.1016/j.rbmo.2023.103738 |
| PMID: | 38701633 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1472-6491 |
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| DOI: | 10.1016/j.rbmo.2023.103738 |