دورية أكاديمية
أعرض في EDS

H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency.

التفاصيل البيبلوغرافية
العنوان: H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency.
المؤلفون: Kunitomi A; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA. Electronic address: akira.kunitomi@gladstone.ucsf.edu., Hirohata R; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CiRA Foundation, Kyoto 606-8397, Japan., Osawa M; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan., Washizu K; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA., Arreola V; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA., Saiki N; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan., Kato TM; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CiRA Foundation, Kyoto 606-8397, Japan., Nomura M; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CiRA Foundation, Kyoto 606-8397, Japan., Kunitomi H; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA., Ohkame T; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan., Ohkame Y; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan., Kawaguchi J; ID Pharma Co., Ltd, Ibaraki 300-2611, Japan., Hara H; ID Pharma Co., Ltd, Ibaraki 300-2611, Japan., Kusano K; ID Pharma Co., Ltd, Ibaraki 300-2611, Japan., Yamamoto T; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto 606-8501, Japan; Medical-risk Avoidance Based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto 606-8507, Japan., Takashima Y; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan., Tohyama S; Department of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan., Yuasa S; Department of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan., Fukuda K; Department of Cardiology, Keio University School of Medicine, Tokyo 160-8582, Japan., Takasu N; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CiRA Foundation, Kyoto 606-8397, Japan., Yamanaka S; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; CiRA Foundation, Kyoto 606-8397, Japan; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
المصدر: Stem cell reports [Stem Cell Reports] 2024 May 14; Vol. 19 (5), pp. 710-728. Date of Electronic Publication: 2024 May 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2013-
مواضيع طبية MeSH: Kruppel-Like Factor 4* , Cellular Reprogramming*/genetics , Induced Pluripotent Stem Cells*/cytology , Induced Pluripotent Stem Cells*/metabolism , Histones*/metabolism, Humans ; Cell Differentiation/genetics ; Kruppel-Like Transcription Factors/metabolism ; Kruppel-Like Transcription Factors/genetics ; SOXB1 Transcription Factors/metabolism ; SOXB1 Transcription Factors/genetics ; Chromatin/metabolism ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/cytology ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Transcriptome
مستخلص: Heterogeneity among both primed and naive pluripotent stem cell lines remains a major unresolved problem. Here we show that expressing the maternal-specific linker histone H1FOO fused to a destabilizing domain (H1FOO-DD), together with OCT4, SOX2, KLF4, and LMYC, in human somatic cells improves the quality of reprogramming to both primed and naive pluripotency. H1FOO-DD expression was associated with altered chromatin accessibility around pluripotency genes and with suppression of the innate immune response. Notably, H1FOO-DD generates naive induced pluripotent stem cells with lower variation in transcriptome and methylome among clones and a more uniform and superior differentiation potency. Furthermore, we elucidated that upregulation of FKBP1A, driven by these five factors, plays a key role in H1FOO-DD-mediated reprogramming.
Competing Interests: Declaration of interests A.K. and K.F. are co-inventors on a patent describing the method for producing human iPSCs from somatic cells using H1FOO-DD. K.F. is a co-founder and CEO of Heartseed Inc., and S.T., S. Yuasa, and K.F. own equity in Heartseed Inc. S.T. is an advisor of Heartseed Inc. J.K. and H.H. are employees and K.K. is a board member of ID Pharma Co., Ltd., without compensation relating to this study. S. Yamanaka is a scientific advisor to iPS Academia Japan without salary.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
References: Development. 2001 Mar;128(5):655-64. (PMID: 11171391)
Stem Cell Reports. 2016 Jun 14;6(6):825-833. (PMID: 27237376)
Cell Stem Cell. 2017 Jan 5;20(1):87-101. (PMID: 27989770)
Nat Protoc. 2007;2(12):3081-9. (PMID: 18079707)
Cell Stem Cell. 2020 Oct 1;27(4):523-531. (PMID: 33007237)
Nat Biotechnol. 2015 Nov;33(11):1182-92. (PMID: 26501952)
Cell Rep. 2021 Jun 15;35(11):109233. (PMID: 34133938)
Stem Cell Reports. 2019 Dec 10;13(6):1083-1098. (PMID: 31708477)
Nat Rev Mol Cell Biol. 2016 Mar;17(3):155-69. (PMID: 26860365)
Proc Jpn Acad Ser B Phys Biol Sci. 2009;85(8):348-62. (PMID: 19838014)
Cell Stem Cell. 2021 Jun 3;28(6):1023-1039.e13. (PMID: 33831365)
Nat Struct Mol Biol. 2013 Sep;20(9):1131-9. (PMID: 23934149)
Nat Methods. 2017 Nov;14(11):1055-1062. (PMID: 28945704)
Stem Cell Rev Rep. 2020 Feb;16(1):3-32. (PMID: 31760627)
Cell Stem Cell. 2014 Oct 2;15(4):524-526. (PMID: 28903030)
Nature. 2007 Jul 19;448(7151):313-7. (PMID: 17554338)
Cell Rep Methods. 2022 Oct 17;2(11):100317. (PMID: 36447645)
Cell. 2013 Mar 14;152(6):1324-43. (PMID: 23498940)
Cell Stem Cell. 2014 Jun 5;14(6):720-34. (PMID: 24905163)
Cell Stem Cell. 2009 Jun 5;4(6):487-92. (PMID: 19497275)
Science. 1998 Nov 6;282(5391):1145-7. (PMID: 9804556)
Nat Biotechnol. 2008 Jan;26(1):101-6. (PMID: 18059259)
Cell Stem Cell. 2017 Dec 7;21(6):791-805.e9. (PMID: 29174331)
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12172-9. (PMID: 23812749)
Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5697-702. (PMID: 15821029)
Nat Commun. 2014 Apr 24;5:3678. (PMID: 24759836)
Mol Cell Endocrinol. 2003 Apr 28;202(1-2):5-9. (PMID: 12770723)
Epigenetics. 2016;11(1):85-94. (PMID: 26901819)
Cell. 2014 Sep 11;158(6):1254-1269. (PMID: 25215486)
Cell Stem Cell. 2017 Dec 7;21(6):819-833.e6. (PMID: 29220666)
EMBO J. 1997 Jul 1;16(13):3866-76. (PMID: 9233797)
Nature. 2021 Mar;591(7851):620-626. (PMID: 33731924)
Cell. 2006 Sep 8;126(5):995-1004. (PMID: 16959577)
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14152-7. (PMID: 20660764)
Stem Cell Reports. 2015 Apr 14;4(4):645-57. (PMID: 25801506)
Exp Cell Res. 1995 Oct;220(2):501-4. (PMID: 7556460)
FEBS Lett. 2018 Jul;592(14):2414-2424. (PMID: 29963710)
Nature. 2021 Mar;591(7851):627-632. (PMID: 33731926)
J Virol. 2000 Jul;74(14):6564-9. (PMID: 10864670)
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1384-1393. (PMID: 30606801)
Cell Stem Cell. 2010 Nov 5;7(5):618-30. (PMID: 20888316)
Science. 2004 Mar 5;303(5663):1529-31. (PMID: 14976261)
Sci Rep. 2021 Dec 20;11(1):24254. (PMID: 34930932)
J Mol Endocrinol. 2006 Jun;36(3):569-79. (PMID: 16720724)
Nat Commun. 2018 Jan 24;9(1):360. (PMID: 29367672)
Elife. 2019 Mar 12;8:. (PMID: 30860479)
فهرسة مساهمة: Keywords: FKBP1A; H1FOO; Sendai virus vector; destabilized domain; heterogeneity; induced pluripotent stem cell; innate immune response; naive pluripotency; primed pluripotency; reprogramming
تواريخ الأحداث: Date Created: 20240503 Date Completed: 20240515 Latest Revision: 20240522
رمز التحديث: 20240522
مُعرف محوري في PubMed: PMC11103934
DOI: 10.1016/j.stemcr.2024.04.005
PMID: 38701780
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-6711
DOI:10.1016/j.stemcr.2024.04.005