دورية أكاديمية
Visual boundary cues suffice to anchor place and grid cells in virtual reality.
| العنوان: | Visual boundary cues suffice to anchor place and grid cells in virtual reality. |
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| المؤلفون: | Yang X; School of Biological and Behavioural Sciences, Queen Mary University of London, 327 Mile End Road, London E1 4NS, UK., Cacucci F; Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK., Burgess N; Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AZ, UK; Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK., Wills TJ; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: t.wills@ucl.ac.uk., Chen G; School of Biological and Behavioural Sciences, Queen Mary University of London, 327 Mile End Road, London E1 4NS, UK. Electronic address: guifen.chen@qmul.ac.uk. |
| المصدر: | Current biology : CB [Curr Biol] 2024 May 20; Vol. 34 (10), pp. 2256-2264.e3. Date of Electronic Publication: 2024 May 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991- |
| مواضيع طبية MeSH: | Virtual Reality* , Cues* , Grid Cells*/physiology, Animals ; Male ; Hippocampus/physiology ; Space Perception/physiology ; Rats ; Place Cells/physiology ; Visual Perception/physiology ; Rats, Long-Evans ; Orientation/physiology |
| مستخلص: | The hippocampal formation contains neurons responsive to an animal's current location and orientation, which together provide the organism with a neural map of space. 1 , 2 , 3 Spatially tuned neurons rely on external landmark cues and internally generated movement information to estimate position. 4 , 5 An important class of landmark cue are the boundaries delimiting an environment, which can define place cell field position 6 , 7 and stabilize grid cell firing. 8 However, the precise nature of the sensory information used to detect boundaries remains unknown. We used 2-dimensional virtual reality (VR) 9 to show that visual cues from elevated walls surrounding the environment are both sufficient and necessary to stabilize place and grid cell responses in VR, when only visual and self-motion cues are available. By contrast, flat boundaries formed by the edges of a textured floor did not stabilize place and grid cells, indicating only specific forms of visual boundary stabilize hippocampal spatial firing. Unstable grid cells retain internally coherent, hexagonally arranged firing fields, but these fields "drift" with respect to the virtual environment over periods >5 s. Optic flow from a virtual floor does not slow drift dynamics, emphasizing the importance of boundary-related visual information. Surprisingly, place fields are more stable close to boundaries even with floor and wall cues removed, suggesting invisible boundaries are inferred using the motion of a discrete, separate cue (a beacon signaling reward location). Subsets of place cells show allocentric directional tuning toward the beacon, with strength of tuning correlating with place field stability when boundaries are removed. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: boundary; grid cells; hippocampus; place cells; virtual reality; visual cues |
| تواريخ الأحداث: | Date Created: 20240503 Date Completed: 20240521 Latest Revision: 20240523 |
| رمز التحديث: | 20240524 |
| DOI: | 10.1016/j.cub.2024.04.026 |
| PMID: | 38701787 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1879-0445 |
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| DOI: | 10.1016/j.cub.2024.04.026 |