دورية أكاديمية
Epigallocatechin gallate protects against fat and muscle atrophy in B16BL6 melanoma-bearing mice on a high-fat diet.
| العنوان: | Epigallocatechin gallate protects against fat and muscle atrophy in B16BL6 melanoma-bearing mice on a high-fat diet. |
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| المؤلفون: | Park WY; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Song G; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Park JY; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Jung SJ; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Kim S; Department of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Ahn KS; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Choe SK; Department of Microbiology, Wonkwang University School of Medicine, Iksan 54538, Republic of Korea., Kwak HJ; Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea., Park J; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea., Um JY; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: jyum@khu.ac.kr. |
| المصدر: | Life sciences [Life Sci] 2024 Jul 01; Vol. 348, pp. 122677. Date of Electronic Publication: 2024 May 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Catechin*/analogs & derivatives , Catechin*/pharmacology , Catechin*/therapeutic use , Diet, High-Fat*/adverse effects , Muscular Atrophy*/prevention & control , Muscular Atrophy*/metabolism , Muscular Atrophy*/drug therapy , Mice, Inbred C57BL* , Melanoma, Experimental*/drug therapy , Melanoma, Experimental*/metabolism , Melanoma, Experimental*/pathology, Animals ; Mice ; Male ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Obesity/metabolism ; Obesity/drug therapy ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology |
| مستخلص: | Aims: Epidemiological evidence indicates that there is a substantial association between body mass index (BMI) and at least ten forms of cancer, including melanoma, and BMI imbalance contributes to the poor survival rate of cancer patients before and after therapy. Nevertheless, few pharmacological studies on models of obesity and cancer have been reported. In this study, we administered epigallocatechin gallate (EGCG) to B16BL6 tumor-bearing mice that received a high-fat diet (HFD) to examine its impact. Methods: B16BL6 tumor-bearing mice were fed a HFD. Body weight and food intake were documented every week. We conducted a Western blot analysis to examine the protein levels in the tumor, gastrocnemius (GAS), and tibialis anterior (TA) muscles, as well as the inguinal and epididymal white adipose tissues (iWAT and eWAT). Key Findings: EGCG has been shown to have anti-cancer effects equivalent to those of cisplatin, a chemotherapy drug. Furthermore, EGCG protected against the loss of epidydimal white adipose tissue by regulating protein levels of lipolysis factors of adipose triglyceride lipase and hormone-sensitive lipase as well as WAT browning factors of uncoupling protein 1, as opposed to cisplatin. EGCG was shown to reduce the protein levels of muscular atrophy factors of muscle RING-finger protein-1, whereas cisplatin did not contribute to rescuing the atrophy of TA and GAS muscles. Conclusion: Taken together, our findings indicate that EGCG has a preventive effect against cachexia symptoms and has anti-cancer effects similar to those of cisplatin in tumor-bearing mice fed a high-fat diet. Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: B16BL6 melanoma; EGCG; High-fat diet; Lipolysis; Muscle atrophy |
| المشرفين على المادة: | 0 (epigallocatechin gallate) |
| تواريخ الأحداث: | Date Created: 20240503 Date Completed: 20240521 Latest Revision: 20240521 |
| رمز التحديث: | 20240522 |
| DOI: | 10.1016/j.lfs.2024.122677 |
| PMID: | 38702026 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
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| DOI: | 10.1016/j.lfs.2024.122677 |