دورية أكاديمية
أعرض في EDS

Association of osteoporotic fractures of femoral neck and femoral neck geometric parameters in native Chinese women.

التفاصيل البيبلوغرافية
العنوان: Association of osteoporotic fractures of femoral neck and femoral neck geometric parameters in native Chinese women.
المؤلفون: Li L; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya, Hospital of Central South University, Changsha, 410011, China.; Department of Endocrinology and Metabolism, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, China., Shen Y; Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, 410011, China., Tan LH; Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China., Zhang H; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya, Hospital of Central South University, Changsha, 410011, China., Dai RC; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya, Hospital of Central South University, Changsha, 410011, China., Yuan LQ; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya, Hospital of Central South University, Changsha, 410011, China., Sheng ZF; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya, Hospital of Central South University, Changsha, 410011, China., Wu XY; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya, Hospital of Central South University, Changsha, 410011, China. wuxiyu640@csu.edu.cn.
المصدر: BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2024 May 03; Vol. 25 (1), pp. 349. Date of Electronic Publication: 2024 May 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Osteoporotic Fractures*/epidemiology , Osteoporotic Fractures*/diagnostic imaging , Femoral Neck Fractures*/diagnostic imaging , Femoral Neck Fractures*/epidemiology , Femoral Neck Fractures*/ethnology , Femur Neck*/diagnostic imaging , Bone Density* , Absorptiometry, Photon*, Humans ; Female ; Aged ; Middle Aged ; China/epidemiology ; Aged, 80 and over ; Case-Control Studies ; Asian People ; Risk Factors ; East Asian People
مستخلص: Background: Although it is generally believed that the femoral neck fracture is related to the femoral neck geometric parameters (FNGPs), the association between the risk of osteoporotic fracture of the femoral neck and FNGPs in native Chinese women is still unclear.
Methods: A total of 374 female patients (mean age 70.2 ± 9.32 years) with osteoporotic fracture of the femoral neck, and 374 non-fracture control groups were completely matched with the case group according to the age ratio of 1:1. Using DXA bone densitometer to measured eight FNGPs: the outer diameter (OD), cross-sectional area (CSA), cortical thickness (CT), endocortical diameter (ED), buckling ratio (BR), section modulus (SM), cross-sectional moment of inertia (CSMI), and compressive strength index (CSI) at the narrowest point of the femoral neck.
Results: Compared with the control group, the average values of OD (2.9%), ED (4.5%), and BR (26.1%) in the patient group significantly increased (p = 0.015 to < 0.001), while CSA (‒15.3%), CT (‒18.2%), SM (‒10.3%), CSMI (‒6.4%), and CSI (‒10.8%) significantly decreased (all p < 0.001). The prevalence of osteoporosis in the lumbar spine, femoral neck, and total hip was, respectively, 82%, 81%, and 65% in fracture patients. Cox proportional hazard model analysis showed that in the age adjusted model, the fracture hazard ratio (HR) of CSA, CT, BR, SM, and CSI significantly increased (HRs = 1.60‒8.33; 95% CI = 1.08‒16.6; all p < 0.001). In the model adjusted for age and femoral neck BMD, HRs of CT (HRs = 3.90‒8.03; 95% CI = 2.45‒15.1; all p < 0.001) and BR (HRs = 1.62‒2.60; 95% CI = 1.20‒5.44; all p < 0.001) were still significantly increased.
Conclusion: These results suggest that the majority of osteoporotic fractures of the femoral neck of native Chinese women occur in patients with osteoporosis. CT thinning or BR increase of FNGPs may be independent predictors of fragility fracture of femoral neck in native Chinese women unrelated to BMD.
(© 2024. The Author(s).)
References: Acta Orthop. 2014 Feb;85(1):54-9. (PMID: 24397744)
Bone. 2004 Jan;34(1):195-202. (PMID: 14751578)
Eur Radiol. 2010 Nov;20(11):2707-14. (PMID: 20559834)
J Bone Miner Res. 2012 Jan;27(1):125-9. (PMID: 21956596)
CMAJ. 2007 Sep 11;177(6):575-80. (PMID: 17846439)
Arch Intern Med. 2004 May 24;164(10):1108-12. (PMID: 15159268)
Osteoporos Int. 2013 Oct;24(10):2725-8. (PMID: 23632827)
Acta Orthop. 2021 Jun;92(3):292-296. (PMID: 33478319)
Osteoporos Int. 2012 Sep;23(9):2239-56. (PMID: 22419370)
JAMA. 2005 May 4;293(17):2102-8. (PMID: 15870413)
Osteoporos Int. 2011 Jun;22(6):1987-96. (PMID: 20882272)
Ther Adv Musculoskelet Dis. 2022 Oct 28;14:1759720X221133429. (PMID: 36317067)
Zhonghua Liu Xing Bing Xue Za Zhi. 2008 Nov;29(11):1128-31. (PMID: 19173940)
Osteoporos Int. 2004 Dec;15(12):998-1002. (PMID: 15156304)
Osteoporos Int. 2009 Oct;20(10):1767-74. (PMID: 19238304)
J Orthop Surg (Hong Kong). 2015 Aug;23(2):150-4. (PMID: 26321539)
Osteoporos Int. 2012 Apr;23(4):1393-8. (PMID: 21786006)
Osteoporos Int. 2004 Jan;15(1):71-9. (PMID: 14598027)
Osteoporos Int. 2013 Apr;24(4):1379-88. (PMID: 22810918)
J Clin Densitom. 2018 Oct - Dec;21(4):550-562. (PMID: 28624339)
J Bone Metab. 2016 Aug;23(3):175-82. (PMID: 27622182)
Osteoporos Int. 2004 Jan;15(1):62-70. (PMID: 14605798)
Osteoporos Int. 2003;14 Suppl 3:S13-8. (PMID: 12730800)
Osteoporos Int. 2011 May;22(5):1377-88. (PMID: 20737265)
Osteoporos Int. 2010 Jul;21(7):1205-14. (PMID: 19802512)
Osteoporos Int. 2010 Aug;21(8):1317-22. (PMID: 19802507)
Osteoporos Int. 2006 Feb;17(2):231-6. (PMID: 15983728)
Osteoporos Int. 2011 Oct;22(10):2575-86. (PMID: 21484361)
Aging Clin Exp Res. 2015 Oct;27 Suppl 1:S17-21. (PMID: 26178633)
Bone. 2008 Mar;42(3):467-75. (PMID: 18180210)
Injury. 2018 Aug;49(8):1445-1450. (PMID: 29983171)
J Bone Miner Res. 2003 Oct;18(10):1766-74. (PMID: 14584886)
Osteoporos Int. 2006;17(9):1404-9. (PMID: 16699736)
Injury. 2002 Dec;33 Suppl 3:C1-7. (PMID: 12423584)
Bone. 2016 Dec;93:64-70. (PMID: 27641474)
J Orthop Translat. 2018 Jan 05;13:1-6. (PMID: 29662785)
J Clin Endocrinol Metab. 2005 May;90(5):2787-93. (PMID: 15728213)
Clin Orthop Relat Res. 2011 Mar;469(3):884-9. (PMID: 20725817)
J Intern Med. 2022 Apr;291(4):481-492. (PMID: 34875136)
Acta Orthop. 2020 Feb;91(1):1-75. (PMID: 31801400)
J Bone Miner Res. 2003 Nov;18(11):1947-54. (PMID: 14606506)
J Bone Joint Surg Am. 2008 Jul;90(7):1436-42. (PMID: 18594090)
J Bone Miner Res. 2004 Dec;19(12):1945-54. (PMID: 15537436)
Appl Radiat Isot. 1999 Jan;50(1):215-36. (PMID: 10028639)
معلومات مُعتمدة: 81500685 the National Natural Science Foundation of China; 200446850 the Ministry of Health of the People's Republic of China; [2013]15-86 the Clinical Big Data Project of Central South University, China.
فهرسة مساهمة: Keywords: Femoral neck fracture; Femoral neck geometric parameters; Fracture risk; Osteoporosis
تواريخ الأحداث: Date Created: 20240503 Date Completed: 20240504 Latest Revision: 20240706
رمز التحديث: 20240706
مُعرف محوري في PubMed: PMC11067106
DOI: 10.1186/s12891-024-07483-1
PMID: 38702706
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2474
DOI:10.1186/s12891-024-07483-1