دورية أكاديمية
Reproductive and endocrine-disrupting toxicity of pyrogallol in catfish (Clariasgariepinus).
| العنوان: | Reproductive and endocrine-disrupting toxicity of pyrogallol in catfish (Clariasgariepinus). |
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| المؤلفون: | Hamed M; Department of Zoology, Faculty of Science, Al-Azhar University (Assiut Branch), Assiut, 71524, Egypt; Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA. Electronic address: mohamedhamedsayed239@gmail.com., Said REM; Department of Zoology, Faculty of Science, Al-Azhar University (Assiut Branch), Assiut, 71524, Egypt., Martyniuk CJ; Center for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA., Soliman HAM; Department of Zoology, Faculty of Science, Sohag University, Sohag 8562, Egypt., Sayed AEH; Department of Zoology, Faculty of Science, Assiut University, Assiut 71516, Egypt; Molecular Biology Research & Studies Institute, Assiut University, 71516 Assiut, Egypt., Osman AGM; Department of Zoology, Faculty of Science, Al-Azhar University (Assiut Branch), Assiut, 71524, Egypt. |
| المصدر: | Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2024 Jul 01; Vol. 352, pp. 124104. Date of Electronic Publication: 2024 May 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987- |
| مواضيع طبية MeSH: | Catfishes*/physiology , Endocrine Disruptors*/toxicity , Water Pollutants, Chemical*/toxicity , Reproduction*/drug effects , Pyrogallol*/toxicity , Pyrogallol*/analogs & derivatives, Animals ; Male ; Female ; Thyroid Gland/drug effects |
| مستخلص: | Endocrine disruptors are synthetic or natural chemicals that can agonize/antagonize hormone receptors or can interfere with the production and secretion of hormones, leading to altered tissue histology and physiology. Pyrogallol is a contaminant widely distributed in aquatic environments that presents health risks to both humans and animals. However, the potential for endocrine disruption by pyrogallol, particularly in fish, are lacking. The purpose of this study was to shed light on how pyrogallol may affect hormone signalling, histopathology, and reproductive outcomes in African catfish Clarias gariepinus. To investigate this, African catfish were exposed to one sublethal concentration of pyrogallol at either 0, 1, 5 or 10 mg/L for 15 days. We then assessed the effects of pyrogallol on the thyroid gland as well as the reproductive system by measuring sex hormone, seminal quality, gonadal histopathology, and histochemistry. Thyroid stimulating hormone and thyroxine showed notable decreases in catfish, and triiodothyronine was decreased with 10 mg/L pyrogallol. Unlike luteinizing hormone, follicle-stimulating hormone was significantly reduced in fish following exposure to pyrogallol relative to controls. Testosterone was also decreased in fish following pyrogallol exposure, whereas 17β-estradiol increased in catfish exposed to pyrogallol. Additionally, in response to pyrogallol toxicity, sperm quality indices, including count, spermatocrit, motility, and sperm viability were adversely affected in a concentration-dependent manner. Pyrogallol exposure also induced several changes in the gonad following exposure to 1, 5, or 10 mg/L. Deformed tubular structures, vacuolation, thickening of the basement membrane, hypertrophy of the seminiferous tubules, intense melanomacrophage localization, spermatozoa loss, and necrosis were all observed in the testes. In the ovary, atretic follicles, deteriorated mature oocytes, degenerated yolk globules, and an increase in perinucleolar oocytes were observed in catfish exposed to pyrogallol. These findings suggest that pyrogallol may act as endocrine disrupting substance in aquatic environments. Further research on the mechanisms by which pyrogallol impairs endocrine systems, particularly in fish, is recommended. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Clarias gariepinus; Endocrine disruption; Histopathology; Pyrogallol; Reproductive toxicity |
| المشرفين على المادة: | 0 (Endocrine Disruptors) 0 (Water Pollutants, Chemical) 01Y4A2QXY0 (Pyrogallol) |
| تواريخ الأحداث: | Date Created: 20240504 Date Completed: 20240604 Latest Revision: 20240604 |
| رمز التحديث: | 20240605 |
| DOI: | 10.1016/j.envpol.2024.124104 |
| PMID: | 38703978 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6424 |
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| DOI: | 10.1016/j.envpol.2024.124104 |