دورية أكاديمية
CircVDAC3 sequesters microRNA-592 and elevates EIF4E3 expression to inhibit the progression of gastric cancer.
| العنوان: | CircVDAC3 sequesters microRNA-592 and elevates EIF4E3 expression to inhibit the progression of gastric cancer. |
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| المؤلفون: | Yang TN; The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China; Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, PR China., Xiao RW; Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, PR China., Su F; The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China; Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, PR China., Dai HY; Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, PR China., Zhao D; Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, PR China., Guo CH; The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China., Zhu KL; The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China., Jiang N; The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China., Guan QL; Department of Oncology Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, PR China. Electronic address: guanql@lzu.edu.cn., Hou XM; Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, PR China. Electronic address: houxiaoming19@163.com. |
| المصدر: | Translational oncology [Transl Oncol] 2024 Jul; Vol. 45, pp. 101972. Date of Electronic Publication: 2024 May 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Neoplasia Press Country of Publication: United States NLM ID: 101472619 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1936-5233 (Print) Linking ISSN: 19365233 NLM ISO Abbreviation: Transl Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Ann Arbor, MI] : Neoplasia Press |
| مستخلص: | Background: Accumulating evidence has shown that circular RNAs (circRNAs) are involved in gastric cancer (GC) tumorigenesis. However, specific functional circRNAs in GC remain to be discovered, and their underlying mechanisms remain to be elucidated. Methods: CircRNAs that were differentially expressed between GC tissues and controls were analyzed using a circRNA microarray dataset. The expression of circVDAC3 in GC was determined using quantitative real-time PCR (qRT-PCR), and the structural features of circVDAC3 were validated. Cell function assays and animal experiments were conducted to explore the effects of circVDAC3 on GC. Finally, bioinformatics analysis, fluorescent in situ hybridization, and dual luciferase assays were used to analyze the downstream mechanisms of circVDAC3. Results: Our results showed that circVDAC3 was downregulated in GC and inhibited the proliferation and metastasis of GC cells. Mechanistically, circVDAC3 acts as a competing endogenous RNA (ceRNA) of miR-592 and deregulates the repression of EIF4E3 by miR-592. EIF4E3 is downregulated in GC and overexpression of miR-592 or knockdown of EIF4E3 in circVDAC3-overexpressing cells weakens the anticancer effect of circVDAC3. Conclusion: Our study provides evidence that circVDAC3 affects the growth and metastasis of GC cells via the circVDAC3/miR-592/EIF4E3 axis. Our findings offer valuable insights into the mechanisms underlying GC tumorigenesis and suggest novel therapeutic strategies. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: CeRNA; CircVDAC3; EIF4E3; Gastric cancer; MiR-592 |
| تواريخ الأحداث: | Date Created: 20240505 Latest Revision: 20240524 |
| رمز التحديث: | 20240525 |
| مُعرف محوري في PubMed: | PMC11087954 |
| DOI: | 10.1016/j.tranon.2024.101972 |
| PMID: | 38705053 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1936-5233 |
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| DOI: | 10.1016/j.tranon.2024.101972 |