دورية أكاديمية
Thiazolidinediones Decrease the Recurrence of Intracerebral Hemorrhage in Type 2 Diabetes Mellitus Patients: A Nested Case-Control Study.
| العنوان: | Thiazolidinediones Decrease the Recurrence of Intracerebral Hemorrhage in Type 2 Diabetes Mellitus Patients: A Nested Case-Control Study. |
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| المؤلفون: | Chiu CD; School of Medicine, China Medical University, Taichung, Taiwan, cdchiu4046@gmail.com.; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan, cdchiu4046@gmail.com.; Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan, cdchiu4046@gmail.com.; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, cdchiu4046@gmail.com., Chiu YP; School of Medicine, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan., Yip HT; School of Medicine, China Medical University, Taichung, Taiwan.; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan., Ji HR; School of Medicine, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan., Cho DY; Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan., Cheng IH; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen CY; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan. |
| المصدر: | Neuroepidemiology [Neuroepidemiology] 2024 May 03, pp. 1-14. Date of Electronic Publication: 2024 May 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: S. Karger Country of Publication: Switzerland NLM ID: 8218700 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0208 (Electronic) Linking ISSN: 02515350 NLM ISO Abbreviation: Neuroepidemiology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : S. Karger, [1982- |
| مستخلص: | Introduction: Preclinical evidence demonstrated the therapeutic potential of thiazolidinediones (TZDs) for the treatment of intracerebral hemorrhage (ICH). The present study conducted an investigation of cerebrovascular and cardiovascular outcomes following ICH in patients with type 2 diabetes mellitus (T2DM) treated with or without TZDs. Methods: This retrospective nested case-control study used data from the Taiwan National Health Insurance Research Database. A total of 62,515 T2DM patients who were hospitalized with a diagnosis of ICH were enrolled, including 7,603 TZD users. Data for TZD non-users were extracted using propensity score matching. Primary outcomes included death and major adverse cardiovascular events (MACEs), which were defined as a composite of ischemic stroke, hemorrhagic stroke (HS), acute myocardial infarction, and congestive heart failure. Patients aged <20 years with a history of traumatic brain injury or any prior history of MACEs were excluded. Results: TZD users had significantly lower MACE risks compared with TZD non-users following ICH (adjusted hazard ratio [aHR]: 0.90, 95% confidence interval [CI]: 0.85-0.94, p < 0.001). The most significant MACE difference reported for TZD users was HS, which possessed lower incidence than in TZD non-users, especially for the events that happened within 3 months following ICH (aHR: 0.74, 95% CI: 0.62-0.89 within 1 month, p < 0.01; aHR: 0.68, 95% CI: 0.54-0.85 between 1 and 3 month). Conclusion: The use of TZD in patients with T2DM was associated with a lower risk of subsequent HS and mortality following ICH. (© 2024 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Cardiovascular risk; Recurrent hemorrhagic stroke; Spontaneous intracerebral hemorrhage; Thiazolidinediones; Type 2 diabetes mellitus |
| تواريخ الأحداث: | Date Created: 20240505 Latest Revision: 20240616 |
| رمز التحديث: | 20240617 |
| DOI: | 10.1159/000539001 |
| PMID: | 38705143 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0208 |
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| DOI: | 10.1159/000539001 |