دورية أكاديمية

Challenges and Strategies in Implementing Novel Kidney Protective and Cardioprotective Therapies in Patients With Diabetes and Kidney Disease.

التفاصيل البيبلوغرافية
العنوان: Challenges and Strategies in Implementing Novel Kidney Protective and Cardioprotective Therapies in Patients With Diabetes and Kidney Disease.
المؤلفون: Limonte CP; Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA; Kidney Research Institute, University of Washington, Seattle, WA. Electronic address: climonte@uw.edu., Lamprea-Montealegre JA; Department of Medicine, University of California, San Francisco, CA; Kidney Health Research Collaborative, University of California, San Francisco, CA., Tuttle KR; Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA; Providence Health Care, Spokane, WA.
المصدر: Seminars in nephrology [Semin Nephrol] 2024 Mar; Vol. 44 (2), pp. 151520. Date of Electronic Publication: 2024 May 05.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8110298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-4488 (Electronic) Linking ISSN: 02709295 NLM ISO Abbreviation: Semin Nephrol Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia Pa : W.B. Saunders
Original Publication: [New York, N.Y.] : Grune & Stratton, [c1981-
مواضيع طبية MeSH: Renal Insufficiency, Chronic*/therapy , Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use, Humans ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Cardiovascular Diseases/prevention & control ; Glucagon-Like Peptide-1 Receptor/agonists ; Diabetic Nephropathies/prevention & control ; Diabetic Nephropathies/therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/therapy
مستخلص: Chronic kidney disease (CKD) is highly prevalent, estimated to affect over 800 million people worldwide. Diabetes is a leading cause of kidney disease. Both diabetes and CKD are associated with a high risk of cardiovascular disease and related morbidity and mortality. Over the last several years, there has been a shift in focus toward integrating kidney and cardiovascular care, particularly in diabetes. Sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 receptor agonists, and nonsteroidal mineralocorticoid receptor antagonists have rapidly become cornerstones of kidney and cardiovascular risk-focused care in diabetes and CKD. However, present-day use of these agents is low, and disparities in use by race, ethnicity, age, sex, and comorbidities are apparent. Challenges in implementation of kidney protective and cardioprotective therapies include low rates of diabetes and CKD screening, lack of provider comfort and subspecialty reliance, inconsistencies across professional society guidelines, high rates of drug discontinuation, and prohibitive costs. Effective implementation of kidney protective and cardioprotective therapies necessitates a multifaceted approach and active engagement of patients, pharmacists, primary care providers, subspecialty providers, and health care system leaders as key stakeholders. Implementation efforts should be practical and incorporate collaborative, multidisciplinary team-based approaches. Successful implementation of kidney protective and cardioprotective therapies has the potential to improve overall health outcomes and ameliorate health care disparities.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: K23 DK135789 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Chronic kidney disease; GLP-1 RA; SGLT2; diabetes; implementation
المشرفين على المادة: 0 (Sodium-Glucose Transporter 2 Inhibitors)
0 (Mineralocorticoid Receptor Antagonists)
0 (Glucagon-Like Peptide-1 Receptor)
تواريخ الأحداث: Date Created: 20240505 Date Completed: 20240728 Latest Revision: 20240730
رمز التحديث: 20240730
مُعرف محوري في PubMed: PMC11283968
DOI: 10.1016/j.semnephrol.2024.151520
PMID: 38705774
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-4488
DOI:10.1016/j.semnephrol.2024.151520