دورية أكاديمية
Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping.
العنوان: | Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping. |
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المؤلفون: | Skouras S; Department of Fundamental Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.; Department of Neurology, Inselspital University Hospital Bern, CH3010 Bern, Switzerland., Kleinert ML; Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain., Lee EHM; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Hui CLM; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Suen YN; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Camchong J; Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA., Chong CSY; Department of Psychiatry, Kwai Chung Hospital, Hong Kong, China., Chang WC; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Chan SKW; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Lo WTL; Department of Psychiatry, Kwai Chung Hospital, Hong Kong, China., Lim KO; Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA., Chen EYH; Department of Psychiatry, University of Hong Kong, Hong Kong, China. |
المصدر: | Brain communications [Brain Commun] 2024 May 04; Vol. 6 (3), pp. fcae094. Date of Electronic Publication: 2024 May 04 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Oxford] : Oxford University Press, [2019]- |
مستخلص: | Functional connectivity resting-state functional magnetic resonance imaging has been proposed to predict antipsychotic treatment response in schizophrenia. However, only a few prospective studies have examined baseline resting-state functional magnetic resonance imaging data in drug-naïve first-episode schizophrenia patients with regard to subsequent treatment response. Data-driven approaches to conceptualize and measure functional connectivity patterns vary broadly, and model-free, voxel-wise, whole-brain analysis techniques are scarce. Here, we apply such a method, called connectivity concordance mapping to resting-state functional magnetic resonance imaging data acquired from an Asian sample ( n = 60) with first-episode psychosis, prior to pharmaceutical treatment. Using a longitudinal design, 12 months after the resting-state functional magnetic resonance imaging, we measured and classified patients into two groups based on psychometric testing: treatment responsive and treatment resistant. Next, we compared the two groups' connectivity concordance maps that were derived from the resting-state functional magnetic resonance imaging data at baseline. We have identified consistently higher functional connectivity in the treatment-resistant group in a network including the left hippocampus, bilateral insula and temporal poles. These data-driven novel findings can help researchers to consider new regions of interest and facilitate biomarker development in order to identify treatment-resistant schizophrenia patients early, in advance of treatment and at the time of their first psychotic episode. Competing Interests: The authors report no competing interests. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.) |
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فهرسة مساهمة: | Keywords: connectivity concordance mapping; fMRI; resting-state; schizophrenia; treatment resistant |
تواريخ الأحداث: | Date Created: 20240506 Latest Revision: 20240507 |
رمز التحديث: | 20240507 |
مُعرف محوري في PubMed: | PMC11069118 |
DOI: | 10.1093/braincomms/fcae094 |
PMID: | 38707706 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2632-1297 |
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DOI: | 10.1093/braincomms/fcae094 |