دورية أكاديمية
أعرض في EDS

Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping.

التفاصيل البيبلوغرافية
العنوان: Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping.
المؤلفون: Skouras S; Department of Fundamental Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.; Department of Neurology, Inselspital University Hospital Bern, CH3010 Bern, Switzerland., Kleinert ML; Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain., Lee EHM; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Hui CLM; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Suen YN; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Camchong J; Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA., Chong CSY; Department of Psychiatry, Kwai Chung Hospital, Hong Kong, China., Chang WC; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Chan SKW; Department of Psychiatry, University of Hong Kong, Hong Kong, China., Lo WTL; Department of Psychiatry, Kwai Chung Hospital, Hong Kong, China., Lim KO; Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA., Chen EYH; Department of Psychiatry, University of Hong Kong, Hong Kong, China.
المصدر: Brain communications [Brain Commun] 2024 May 04; Vol. 6 (3), pp. fcae094. Date of Electronic Publication: 2024 May 04 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Oxford University Press, [2019]-
مستخلص: Functional connectivity resting-state functional magnetic resonance imaging has been proposed to predict antipsychotic treatment response in schizophrenia. However, only a few prospective studies have examined baseline resting-state functional magnetic resonance imaging data in drug-naïve first-episode schizophrenia patients with regard to subsequent treatment response. Data-driven approaches to conceptualize and measure functional connectivity patterns vary broadly, and model-free, voxel-wise, whole-brain analysis techniques are scarce. Here, we apply such a method, called connectivity concordance mapping to resting-state functional magnetic resonance imaging data acquired from an Asian sample ( n = 60) with first-episode psychosis, prior to pharmaceutical treatment. Using a longitudinal design, 12 months after the resting-state functional magnetic resonance imaging, we measured and classified patients into two groups based on psychometric testing: treatment responsive and treatment resistant. Next, we compared the two groups' connectivity concordance maps that were derived from the resting-state functional magnetic resonance imaging data at baseline. We have identified consistently higher functional connectivity in the treatment-resistant group in a network including the left hippocampus, bilateral insula and temporal poles. These data-driven novel findings can help researchers to consider new regions of interest and facilitate biomarker development in order to identify treatment-resistant schizophrenia patients early, in advance of treatment and at the time of their first psychotic episode.
Competing Interests: The authors report no competing interests.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.)
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فهرسة مساهمة: Keywords: connectivity concordance mapping; fMRI; resting-state; schizophrenia; treatment resistant
تواريخ الأحداث: Date Created: 20240506 Latest Revision: 20240507
رمز التحديث: 20240507
مُعرف محوري في PubMed: PMC11069118
DOI: 10.1093/braincomms/fcae094
PMID: 38707706
قاعدة البيانات: MEDLINE
الوصف
تدمد:2632-1297
DOI:10.1093/braincomms/fcae094