دورية أكاديمية
أعرض في EDS

Engineering Stem Cell Fate Controlling Biomaterials to Develop Muscle Connective Tissue Layered Myofibers.

التفاصيل البيبلوغرافية
العنوان: Engineering Stem Cell Fate Controlling Biomaterials to Develop Muscle Connective Tissue Layered Myofibers.
المؤلفون: Han S; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea., Lee MC; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Rodríguez-delaRosa A; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Harvard University, Boston, MA 02138, USA., Kim J; Department of Medical Biotechnology, Dongguk University, 32 Dongguk-ro, Goyang 10326, Republic of Korea., Barroso-Zuppa M; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; School of Medicine and Health Sciences, Tecnologico de Monterrey, Mexico City 14380, Mexico.; School of Medicine, Boston University, 72 East Concord Street, Boston, MA 02118, USA., Pineda-Rosales M; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; School of Engineering and Science, Tecnologico de Monterrey, Santiago de Querétaro, Querétaro 76130, Mexico., Kim SS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Hatanaka T; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; Future Mobility Research Department, Toyota Research Institute North America, Toyota Motor North America Inc., Ann Arbor, MI 48105, USA., Yazdi IK; School of Arts and Sciences, Regis College, Weston, MA 02493, USA.; LiquiGlide Inc., Cambridge, MA 02139, USA., Bassous N; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Sinha I; Division of Plastic Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Pourquié O; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Harvard University, Boston, MA 02138, USA., Park S; School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea., Shin SR; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
المصدر: Advanced functional materials [Adv Funct Mater] 2024 Jan 15; Vol. 34 (3). Date of Electronic Publication: 2023 Oct 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101190390 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1616-301X (Print) Linking ISSN: 1616301X NLM ISO Abbreviation: Adv Funct Mater Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2001-
مستخلص: Skeletal muscle connective tissue (MCT) surrounds myofiber bundles to provide structural support, produce force transduction from tendons, and regulate satellite cell differentiation during muscle regeneration. Engineered muscle tissue composed of myofibers layered within MCT has not yet been developed. Herein, a bioengineering strategy to create MCT-layered myofibers through the development of stem cell fate-controlling biomaterials that achieve both myogenesis and fibroblast differentiation in a locally controlled manner at the single construct is introduced. The reciprocal role of transforming growth factor-beta 1 (TGF- β 1) and its inhibitor as well as 3D matrix stiffness to achieve co-differentiation of MCT fibroblasts and myofibers from a human-induced pluripotent stem cell (hiPSC)-derived paraxial mesoderm is studied. To avoid myogenic inhibition, TGF- β 1 is conjugated on the gelatin-based hydrogel to control the fibroblasts' populations locally; the TGF- β 1 degrades after 2 weeks, resulting in increased MCT-specific extracellular matrix (ECM) production. The locations of myofibers and fibroblasts are precisely controlled by using photolithography and co-axial wet spinning techniques, which results in the formation of MCT-layered functional myofibers in 3D constructs. This advanced engineering strategy is envisioned as a possible method for obtaining biomimetic human muscle grafts for various biomedical applications.
Competing Interests: Conflict of Interest The authors declare no conflict of interest.
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معلومات مُعتمدة: R01 AR077132 United States AR NIAMS NIH HHS; R21 EB026824 United States EB NIBIB NIH HHS
فهرسة مساهمة: Keywords: TGF-β1; connective tissues; fibroblast; human-induced pluripotent stem cells; myofibers; tissue engineering
تواريخ الأحداث: Date Created: 20240506 Latest Revision: 20240507
رمز التحديث: 20240507
مُعرف محوري في PubMed: PMC11068219
DOI: 10.1002/adfm.202304153
PMID: 38707790
قاعدة البيانات: MEDLINE
الوصف
تدمد:1616-301X
DOI:10.1002/adfm.202304153