دورية أكاديمية
Engineering Stem Cell Fate Controlling Biomaterials to Develop Muscle Connective Tissue Layered Myofibers.
العنوان: | Engineering Stem Cell Fate Controlling Biomaterials to Develop Muscle Connective Tissue Layered Myofibers. |
---|---|
المؤلفون: | Han S; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea., Lee MC; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Rodríguez-delaRosa A; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Harvard University, Boston, MA 02138, USA., Kim J; Department of Medical Biotechnology, Dongguk University, 32 Dongguk-ro, Goyang 10326, Republic of Korea., Barroso-Zuppa M; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; School of Medicine and Health Sciences, Tecnologico de Monterrey, Mexico City 14380, Mexico.; School of Medicine, Boston University, 72 East Concord Street, Boston, MA 02118, USA., Pineda-Rosales M; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; School of Engineering and Science, Tecnologico de Monterrey, Santiago de Querétaro, Querétaro 76130, Mexico., Kim SS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Hatanaka T; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.; Future Mobility Research Department, Toyota Research Institute North America, Toyota Motor North America Inc., Ann Arbor, MI 48105, USA., Yazdi IK; School of Arts and Sciences, Regis College, Weston, MA 02493, USA.; LiquiGlide Inc., Cambridge, MA 02139, USA., Bassous N; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Sinha I; Division of Plastic Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Pourquié O; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Harvard University, Boston, MA 02138, USA., Park S; School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea., Shin SR; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. |
المصدر: | Advanced functional materials [Adv Funct Mater] 2024 Jan 15; Vol. 34 (3). Date of Electronic Publication: 2023 Oct 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101190390 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1616-301X (Print) Linking ISSN: 1616301X NLM ISO Abbreviation: Adv Funct Mater Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Weinheim, Germany : Wiley-VCH, c2001- |
مستخلص: | Skeletal muscle connective tissue (MCT) surrounds myofiber bundles to provide structural support, produce force transduction from tendons, and regulate satellite cell differentiation during muscle regeneration. Engineered muscle tissue composed of myofibers layered within MCT has not yet been developed. Herein, a bioengineering strategy to create MCT-layered myofibers through the development of stem cell fate-controlling biomaterials that achieve both myogenesis and fibroblast differentiation in a locally controlled manner at the single construct is introduced. The reciprocal role of transforming growth factor-beta 1 (TGF- β 1) and its inhibitor as well as 3D matrix stiffness to achieve co-differentiation of MCT fibroblasts and myofibers from a human-induced pluripotent stem cell (hiPSC)-derived paraxial mesoderm is studied. To avoid myogenic inhibition, TGF- β 1 is conjugated on the gelatin-based hydrogel to control the fibroblasts' populations locally; the TGF- β 1 degrades after 2 weeks, resulting in increased MCT-specific extracellular matrix (ECM) production. The locations of myofibers and fibroblasts are precisely controlled by using photolithography and co-axial wet spinning techniques, which results in the formation of MCT-layered functional myofibers in 3D constructs. This advanced engineering strategy is envisioned as a possible method for obtaining biomimetic human muscle grafts for various biomedical applications. Competing Interests: Conflict of Interest The authors declare no conflict of interest. |
References: | J Cell Biochem. 2006 May 15;98(2):409-20. (PMID: 16440322) Stem Cell Reports. 2018 Jun 5;10(6):1975-1990. (PMID: 29731431) Tissue Eng Part A. 2011 Nov;17(21-22):2641-50. (PMID: 21657983) Nature. 2008 Jul 24;454(7203):528-32. (PMID: 18552838) Aging Cell. 2017 Jun;16(3):518-528. (PMID: 28371268) Head Face Med. 2010 Jul 19;6:17. (PMID: 20642842) Mol Biol Cell. 1993 Jun;4(6):637-45. (PMID: 8374172) Skelet Muscle. 2021 Dec 16;11(1):28. (PMID: 34915930) Nat Cell Biol. 2018 Jan;20(1):46-57. (PMID: 29255171) Nat Cell Biol. 2010 Feb;12(2):153-63. (PMID: 20081841) Adv Healthc Mater. 2022 Feb;11(3):e2101357. (PMID: 34879177) Front Physiol. 2020 Mar 19;11:253. (PMID: 32265741) Cell Tissue Res. 2014 Dec;358(3):857-73. (PMID: 25300647) Development. 2020 Jun 26;147(12):. (PMID: 32541004) J Orthop Res. 2015 Jan;33(1):40-6. (PMID: 25231205) Dev Cell. 2009 Feb;16(2):303-13. (PMID: 19217431) Tissue Eng Part A. 2014 Feb;20(3-4):705-15. (PMID: 24066899) Cell Stem Cell. 2008 May 8;2(5):472-83. (PMID: 18462697) Cell Mol Life Sci. 2019 Jul;76(13):2559-2570. (PMID: 30976839) Nat Protoc. 2016 Oct;11(10):1833-50. (PMID: 27583644) Science. 2005 Nov 18;310(5751):1135-8. (PMID: 16293749) Front Physiol. 2014 Sep 22;5:362. (PMID: 25295011) Small. 2018 Nov;14(48):e1803491. (PMID: 30311453) Biochem Cell Biol. 2003 Dec;81(6):355-63. (PMID: 14663501) Nature. 2011 Jun 08;474(7350):179-83. (PMID: 21654799) Blood. 2009 Feb 5;113(6):1250-6. (PMID: 18945958) Adv Healthc Mater. 2017 Aug;6(16):. (PMID: 28524375) Sci Rep. 2015 Feb 16;5:8480. (PMID: 25684543) Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C763-C771. (PMID: 35876284) Int J Mol Sci. 2015 Mar 11;16(3):5517-27. (PMID: 25768338) Stem Cells Int. 2021 Feb 4;2021:8884283. (PMID: 33628275) Adv Healthc Mater. 2020 Aug;9(16):e2000307. (PMID: 32597577) J Orthop Res. 2019 Jun;37(6):1246-1262. (PMID: 30604468) Sci Signal. 2008 Mar 11;1(10):pe13. (PMID: 18334714) Nat Med. 1996 Apr;2(4):418-23. (PMID: 8597951) Development. 1994 Apr;120(4):925-33. (PMID: 7600968) Am J Pathol. 2004 Mar;164(3):1007-19. (PMID: 14982854) Tissue Cell. 1980;12(1):197-207. (PMID: 7361300) Cell Stem Cell. 2012 May 4;10(5):610-9. (PMID: 22560081) J Physiol. 2017 Aug 1;595(15):5115-5127. (PMID: 28369879) J Clin Invest. 2010 Sep;120(9):3340-9. (PMID: 20679726) Stem Cell Res. 2018 Dec;33:69-78. (PMID: 30321831) Nat Commun. 2020 Feb 24;11(1):1025. (PMID: 32094341) Sci Transl Med. 2012 Jun 27;4(140):140ra89. (PMID: 22745439) Front Physiol. 2020 May 19;11:495. (PMID: 32508678) Front Cell Dev Biol. 2015 May 13;3:29. (PMID: 26029693) Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):. (PMID: 34260377) Dev Dyn. 1997 Apr;208(4):505-15. (PMID: 9097022) Development. 2011 Jan;138(2):371-84. (PMID: 21177349) NPJ Regen Med. 2022 Apr 7;7(1):23. (PMID: 35393412) |
معلومات مُعتمدة: | R01 AR077132 United States AR NIAMS NIH HHS; R21 EB026824 United States EB NIBIB NIH HHS |
فهرسة مساهمة: | Keywords: TGF-β1; connective tissues; fibroblast; human-induced pluripotent stem cells; myofibers; tissue engineering |
تواريخ الأحداث: | Date Created: 20240506 Latest Revision: 20240507 |
رمز التحديث: | 20240507 |
مُعرف محوري في PubMed: | PMC11068219 |
DOI: | 10.1002/adfm.202304153 |
PMID: | 38707790 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1616-301X |
---|---|
DOI: | 10.1002/adfm.202304153 |