دورية أكاديمية
Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status.
| العنوان: | Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status. |
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| المؤلفون: | Kawamura H; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.; Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Koriyama, Fukushima Prefecture, Japan., Ugai T; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA., Takashima Y; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Okadome K; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Shimizu T; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Mima K; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Akimoto N; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Haruki K; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Arima K; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Zhao M; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Väyrynen JP; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Wu K; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA., Zhang X; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Ng K; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA., Nowak JA; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA., Meyerhardt JA; Broad Institute of MIT and Harvard, Cambridge, MA., Giovannucci EL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA., Giannakis M; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Chan AT; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA., Huttenhower C; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA., Garrett WS; Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medicine, Dana-Farber Cancer Institute, Boston, MA., Song M; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA., Ogino S; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA.; Cancer Immunology Program, Dana-Farber Harvard Cancer Center, Boston, MA.; Tokyo Medical and Dental University (Institute of Science Tokyo), Tokyo, Japan. |
| المصدر: | Annals of surgery [Ann Surg] 2024 May 06. Date of Electronic Publication: 2024 May 06. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0372354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1140 (Electronic) Linking ISSN: 00034932 NLM ISO Abbreviation: Ann Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : Lippincott Williams & Wilkins |
| مستخلص: | Objective: To test hypotheses that appendectomy history might lower long-term colorectal cancer risk and that the risk reduction might be strong for tumors enriched with Fusobacterium nucleatum, bacterial species implicated in colorectal carcinogenesis. Background: The absence of the appendix, an immune system organ and a possible reservoir of certain pathogenic microbes, may affect the intestinal microbiome, thereby altering long-term colorectal cancer risk. Methods: Utilizing databases of prospective cohort studies, namely the Nurses' Health Study and the Health Professionals Follow-up Study, we examined the association of appendectomy history with colorectal cancer incidence overall and subclassified by the amount of tumor tissue Fusobacterium nucleatum (Fusobacterium animalis). We used an inverse probability weighted multivariable-adjusted duplication-method Cox proportional hazards regression model. Results: During the follow-up of 139,406 participants (2,894,060 person-years), we documented 2811 incident colorectal cancer cases, of which 1065 cases provided tissue F. nucleatum analysis data. The multivariable-adjusted hazard ratio of appendectomy for overall colorectal cancer incidence was 0.92 (95% CI, 0.84-1.01). Appendectomy was associated with lower F. nucleatum-positive cancer incidence (multivariable-adjusted hazard ratio, 0.53; 95% CI, 0.33-0.85; P=0.0079), but not F. nucleatum-negative cancer incidence (multivariable-adjusted hazard ratio, 0.98; 95% CI, 0.83-1.14), suggesting a differential association by F. nucleatum status (Pheterogeneity=0.015). This differential association appeared to persist in various participant/patient strata including tumor location and microsatellite instability status. Conclusions: Appendectomy likely lowers the future long-term incidence of F. nucleatum-positive (but not F. nucleatum-negative) colorectal cancer. Our findings do not support the existing hypothesis that appendectomy may increase colorectal cancer risk. Competing Interests: A.T.C. previously served as a consultant for Bayer Healthcare and Pfizer Inc. M.G. was on an advisory board for AstraZeneca and receives research funding from Bristol-Myers Squibb. J.A.M. has served as an advisor/consultant to Merck Pharmaceuticals and COTA Healthcare. K.W. is currently a stakeholder and employee of Vertex Pharmaceuticals. This study was not funded by any of these commercial entities. The remaining authors report no conflicts of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| معلومات مُعتمدة: | P01 CA087969 United States CA NCI NIH HHS; U01 CA167552 United States CA NCI NIH HHS; UM1 CA186107 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20240506 Latest Revision: 20240515 |
| رمز التحديث: | 20240515 |
| DOI: | 10.1097/SLA.0000000000006315 |
| PMID: | 38708875 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1528-1140 |
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| DOI: | 10.1097/SLA.0000000000006315 |