دورية أكاديمية
أعرض في EDS

Outcome Measures in Adult Vulvar Lichen Sclerosus: A Case Series of Women Diagnosed as Juveniles.

التفاصيل البيبلوغرافية
العنوان: Outcome Measures in Adult Vulvar Lichen Sclerosus: A Case Series of Women Diagnosed as Juveniles.
المؤلفون: Morrel B, Ten Kate-Booij MJ; Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, the Netherlands., van Dijk C; Department of Dermatology, Sophia Children's Hospital-Center of Pediatric Dermatology, Erasmus MC University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, the Netherlands., van Hees CLM; Department of Dermatology, Sophia Children's Hospital-Center of Pediatric Dermatology, Erasmus MC University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, the Netherlands., Wigny KMGJ; Department of Dermatology, Sophia Children's Hospital-Center of Pediatric Dermatology, Erasmus MC University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, the Netherlands., Burger CW; Research and Development Office (RDO), Erasmus MC University Medical Center Rotterdam, the Netherlands., Pasmans SGMA; Department of Dermatology, Sophia Children's Hospital-Center of Pediatric Dermatology, Erasmus MC University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, the Netherlands., van der Avoort IAM; Department of Obstetrics and Gynecology, Ikazia Hospital, Rotterdam, the Netherlands.
المصدر: Journal of lower genital tract disease [J Low Genit Tract Dis] 2024 Jul 01; Vol. 28 (3), pp. 295-299. Date of Electronic Publication: 2024 May 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9704963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-0976 (Electronic) Linking ISSN: 10892591 NLM ISO Abbreviation: J Low Genit Tract Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Malden, MA : Blackwell Science Inc., c1997-
مواضيع طبية MeSH: Vulvar Lichen Sclerosus*/diagnosis , Quality of Life*, Humans ; Female ; Adult ; Young Adult ; Middle Aged ; Adolescent ; Outcome Assessment, Health Care
مستخلص: Objectives: Studies on the consequences of juvenile vulvar lichen sclerosus (JVLS) in adulthood are limited. A number of measuring tools are available for analyzing adult vulvar lichen sclerosus (VLS), but these have not been applied in studies on JVLS. The aim is to study physical findings, quality of life, sexual well-being, and self-image in adult women with a history of juvenile VLS.
Materials and Methods: Adult women with a biopsy proven history of JVLS were recruited to be examined and surveyed using available standardized measurement tools. This took place in an outpatient setting by physicians who were not involved in the treatment of participants.
Results: Twenty-seven women (median age 29 years) with a history of JVLS and median time since biopsy of 19.5 years were recruited. Of these women, 59% currently had symptoms, 63% had signs of active disease, and 85% had moderate to severe architectural changes. Despite these residual signs, vulvar specific-quality of life and vulvar self-image scored favorably while generic health-related quality of life was somewhat effected.
Conclusions: JVLS has consequences in adulthood involving physical findings and vulvar quality of life. The use of standardized outcome measures for clinical practice and research purposes facilitates a better understanding of the sequelae to JVLS.
Competing Interests: Conflicts of interest: None to declare.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASCCP.)
References: Tasker GL, Wojnarowska F. Lichen sclerosus. Clin Exp Dermatol 2003;28:128–33.
Smith SD, Fischer G. Paediatric vulval lichen sclerosus. Australas J Dermatol 2009;50:243–8.
Powell J, Wojnarowska F. Childhood vulvar lichen sclerosus: an increasingly common problem. J Am Acad Dermatol 2001;44:803–6.
Morrel B, van Eersel R, Burger CW, et al. The long-term clinical consequences of juvenile vulvar lichen sclerosus: a systematic review. J Am Acad Dermatol 2020;82:469–77.
Lagerstedt M, Karvinen K, Joki-Erkkilä M, et al. Childhood lichen sclerosus–a challenge for clinicians. Pediatr Dermatol 2013;30:444–50.
Morrel B, van der Avoort IAM, Ewing-Graham PC, et al. Long-term consequences of juvenile vulvar lichen sclerosus: a cohort study of adults with a histologically confirmed diagnosis in childhood or adolescence. Acta Obstet Gynecol Scand 2023;102:1469–78.
Sheinis M, Selk A. Development of the adult vulvar lichen sclerosus severity scale-a delphi consensus exercise for item generation. J Low Genit Tract Dis 2018;22:66–73.
Erni B, Navarini AA, Huang D, et al. Proposition of a severity scale for lichen sclerosus: the "Clinical Lichen Sclerosus Score". Dermatol Ther 2021;34:e14773.
Hays RD, Morales LS. The RAND-36 measure of health-related quality of life. Ann Med 2001;33:350–7.
Saunderson RB, Harris V, Yeh R, et al. Vulvar quality of life index (VQLI) - a simple tool to measure quality of life in patients with vulvar disease. Australas J Dermatol 2020;61:152–7.
Herbenick D, Reece M. Development and validation of the female genital self-image scale. J Sex Med 2010;7:1822–30.
Winfrey OK, Fei YF, Dendrinos ML, et al. Lichen sclerosus throughout childhood and adolescence: not only a premenarchal disease. J Pediatr Adolesc Gynecol 2022;35:624–8.
Ellis E, Fischer G. Prepubertal-onset vulvar lichen sclerosus: the importance of maintenance therapy in long-term outcomes. Pediatr Dermatol 2015;32:461–7.
De Maeseneer H, Van Gysel D, De Schepper S, et al. Care for children with severe chronic skin diseases. Eur J Pediatr 2019;178:1095–103.
Sheinis M, Green N, Vieira-Baptista P, et al. Adult vulvar lichen sclerosus: can experts agree on the assessment of disease severity? J Low Genit Tract Dis 2020;24:295–8.
Hodges KR, Wiener CE, Vyas AS, et al. The Female Genital Self-image Scale in adult women with vulvar lichen sclerosus. J Low Genit Tract Dis 2019;23:210–3.
Simpson RC, Kirtschig G, Selk A, et al. Core outcome domains for lichen sclerosus: a CORALS initiative consensus statement. Br J Dermatol 2023;188:628–35.
تواريخ الأحداث: Date Created: 20240506 Date Completed: 20240628 Latest Revision: 20240628
رمز التحديث: 20240629
DOI: 10.1097/LGT.0000000000000820
PMID: 38709567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1526-0976
DOI:10.1097/LGT.0000000000000820