دورية أكاديمية
Transcriptomic signatures of progression to TB disease among close contacts in Brazil.
| العنوان: | Transcriptomic signatures of progression to TB disease among close contacts in Brazil. |
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| المؤلفون: | Mendelsohn SC; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Andrade BB; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil., Mbandi SK; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Andrade AMS; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil., Muwanga VM; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Figueiredo MC; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Erasmus M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Rolla VC; Laboratorio de Pesquisa Clinica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-360, Brazil., Thami PK; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Cordeiro-Santos M; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado., Penn-Nicholson A; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.; FIND, 9 Chemin des Mines, 1202, Geneva, Switzerland., Kritski AL; Universidade Federal do Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco, 255, Centro de Pesquisa em Tuberculose, Cidade Universitária, 21941-913, Rio de Janeiro, RJ, Brazil., Hatherill M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Sterling TR; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Scriba TJ; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa. |
| مؤلفون مشاركون: | RePORT-South Africa and RePORT-Brazil Consortia |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2024 May 06. Date of Electronic Publication: 2024 May 06. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مستخلص: | Background: Approximately 5% of people infected with Mycobacterium tuberculosis progress to tuberculosis (TB) disease without preventive therapy. There is a need for a prognostic test to identify those at highest risk of incident TB, so that therapy can be targeted. We evaluated host blood transcriptomic signatures for progression to TB disease. Methods: Close contacts (≥4 hours exposure per week) of adult patients with culture-confirmed pulmonary TB were enrolled in Brazil. Investigation for incident, microbiologically-confirmed or clinically-diagnosed pulmonary or extra-pulmonary TB disease through 24 months of follow-up was symptom-triggered. Twenty previously validated blood TB transcriptomic signatures were measured at baseline by real-time quantitative PCR. Prognostic performance for incident TB was tested using receiver operating characteristic curve (ROC) analysis at 6, 9, 12, and 24 months of follow-up. Results: Between June 2015 and June 2019, 1,854 close contacts were enrolled; Twenty-five progressed to incident TB, of whom 13 had microbiologically-confirmed disease. Baseline transcriptomic signature scores were measured in 1,789 close contacts. Prognostic performance for all signatures was best within 6 months of diagnosis. Seven signatures (Gliddon4, Suliman4, Roe3, Roe1, Penn-Nicholson6, Francisco2, and Rajan5) met the minimum World Health Organization target product profile (TPP) for a prognostic test through 6 months; three (Gliddon4, Rajan5, and Duffy9) through 9 months. None met the TPP threshold through 12 or more months of follow-up. Conclusions: Blood transcriptomic signatures may be useful for predicting TB risk within 9 months of measurement among TB-exposed contacts, to target preventive therapy administration. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| معلومات مُعتمدة: | R01 AI147765 United States AI NIAID NIH HHS; U01 AI172064 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Investigator: N Bilek; Y Cloete; M Erasmus; M Fisher; K Hadley; R Hassiem; M Hatherill; L Jaxa; SK Mbandi; SC Mendelsohn; F Meyer; VM Muwanga; O Nombida; A Penn-Nicholson; R Raphela; TJ Scriba; A September; TR Sterling; PK Thami; A Veldsman; A Andrade; BB Andrade; B Carvalho; M Cordeiro-Santos; MC Figueiredo; A Gomes; AL Kritski; VC Rolla; TR Sterling Keywords: Host; biomarkers; blood; gene; prognostic; transcriptomic; tuberculosis |
| تواريخ الأحداث: | Date Created: 20240506 Latest Revision: 20240509 |
| رمز التحديث: | 20240509 |
| DOI: | 10.1093/infdis/jiae237 |
| PMID: | 38709708 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6613 |
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| DOI: | 10.1093/infdis/jiae237 |