دورية أكاديمية
Non-invasive biomarkers of acute rejection in pediatric kidney transplantation: New targets and strategies.
| العنوان: | Non-invasive biomarkers of acute rejection in pediatric kidney transplantation: New targets and strategies. |
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| المؤلفون: | Pan X; Department of Pediatric surgrey, Guizhou Provincial People's Hospital, Guiyang 550002, China., Peng J; Department of Pediatric surgrey, Guizhou Provincial People's Hospital, Guiyang 550002, China., Zhu R; Department of Pediatric surgrey, Guizhou Provincial People's Hospital, Guiyang 550002, China., An N; Department of Pediatric surgrey, Guizhou Provincial People's Hospital, Guiyang 550002, China., Pei J; Department of Pediatric surgrey, Guizhou Provincial People's Hospital, Guiyang 550002, China. Electronic address: peijun@gz5055.com. |
| المصدر: | Life sciences [Life Sci] 2024 Jul 01; Vol. 348, pp. 122698. Date of Electronic Publication: 2024 May 06. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Kidney Transplantation*/adverse effects , Graft Rejection*/diagnosis , Biomarkers*/urine, Humans ; Child ; Kidney Failure, Chronic/surgery ; Acute Disease |
| مستخلص: | Kidney transplantation is the preferred treatment for pediatric end-stage renal disease. However, pediatric recipients face unique challenges due to their prolonged need for kidney function to accommodate growth and development. The continual changes in the immune microenvironment during childhood development and the heightened risk of complications from long-term use of immunosuppressive drugs. The overwhelming majority of children may require more than one kidney transplant in their lifetime. Acute rejection (AR) stands as the primary cause of kidney transplant failure in children. While pathologic biopsy remains the "gold standard" for diagnosing renal rejection, its invasive nature raises concerns regarding potential functional impairment and the psychological impact on children due to repeated procedures. In this review, we outline the current research status of novel biomarkers associated with AR in urine and blood after pediatric kidney transplantation. These biomarkers exhibit superior diagnostic and prognostic performance compared to conventional ones, with the added advantages of being less invasive and highly reproducible for long-term graft monitoring. We also integrate the limitations of these novel biomarkers and propose a refined monitoring model to optimize the management of AR in pediatric kidney transplantation. Competing Interests: Declaration of competing interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled, “Non-invasive biomarkers of acute rejection in pediatric kidney transplantation: New targets and Strategies”. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acute rejection (AR); Biomarker; Child; Kidney transplant; Non-invasive |
| تواريخ الأحداث: | Date Created: 20240506 Date Completed: 20240521 Latest Revision: 20240521 |
| رمز التحديث: | 20240522 |
| DOI: | 10.1016/j.lfs.2024.122698 |
| PMID: | 38710278 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
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| DOI: | 10.1016/j.lfs.2024.122698 |