دورية أكاديمية
Association between serum antinuclear antibody and rheumatoid arthritis.
| العنوان: | Association between serum antinuclear antibody and rheumatoid arthritis. |
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| المؤلفون: | Liu F; Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Wang XQ; Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Zou JW; Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Li M; Department of Rheumatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Pan CC; Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Si YQ; Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Apr 22; Vol. 15, pp. 1358114. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid*/blood , Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/diagnosis , Antibodies, Antinuclear*/blood , Antibodies, Antinuclear*/immunology, Humans ; Male ; Female ; Middle Aged ; Case-Control Studies ; Adult ; Aged ; Biomarkers/blood ; Risk Factors |
| مستخلص: | Background: The relationship between serum antinuclear antibody (ANA) and rheumatoid arthritis (RA) remains unknown. Therefore, we aimed to evaluate whether serum ANA was associated with an increased risk of RA in a case-control study. Methods: Patients with rheumatoid arthritis hospitalized at Shandong Provincial Hospital from January 2018 to December 2022 were recruited as the case group, and patients with other types of arthritis and healthy people at the same time were taken as the control group. Antinuclear antibody (ANA) was detected by indirect immunofluorescence assays. Propensity score matching was employed to construct a cohort of patients exhibiting comparable baseline characteristics. The relationship between serum ANA and the risk of rheumatoid arthritis was analyzed by logistic regression analysis. Results: A total of 1,175 patients with RA and 1,662 control subjects were included in this study. After adjusting for potential confounding factors in the propensity-score matched cohort, the risk of RA gradually increased with rising of ANA titers. When ANA titers were divided into three groups (1:100, 1:320, and 1:1,000), the OR (95% CI) for ANA titers from low to high was 3.95 (3.01, 5.18), 16.63 (9.44, 29.30), and 17.34 (9.53, 31.54), respectively, compared to those when ANA was negative. The ANA patterns closely related to the occurrence of RA include nuclear homogeneous, nuclear speckled, and cytoplasmic speckled. Among them, the positive rate of nuclear homogeneous was the highest, which accounted for 42.64%. The OR (95% CI) of ANA patterns including nuclear homogeneous, nuclear speckled, and cytoplasmic speckled was 16.81 (11.46, 24.65), 3.40 (2.49, 4.63), and 3.09 (1.77, 5.40), respectively. Conclusion: There was a curve relation between ANA titer and RA, and the higher the ANA titer, the higher the probability of RA. However, there was no statistical difference in probability of RA for 1:320 versus 1:1,000 ANA titers. The most important kind of ANA pattern in the blood of RA patients was nuclear homogeneous. These findings suggest that ANA may be a novel risk marker for RA. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Liu, Wang, Zou, Li, Pan and Si.) |
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| فهرسة مساهمة: | Keywords: antinuclear antibody; correlation analysis; curve relation; rheumatoid arthritis; smooth curve |
| المشرفين على المادة: | 0 (Antibodies, Antinuclear) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240507 Date Completed: 20240507 Latest Revision: 20240508 |
| رمز التحديث: | 20240508 |
| مُعرف محوري في PubMed: | PMC11070521 |
| DOI: | 10.3389/fimmu.2024.1358114 |
| PMID: | 38711518 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2024.1358114 |