التفاصيل البيبلوغرافية
| العنوان: |
HIF-1α is Required to Differentiate the Neonatal Macrophage Secretome from Adults. |
| المؤلفون: |
Becker A, Filipp M, Lantz C, Glinton K, Thorp EB |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 28. Date of Electronic Publication: 2024 Apr 28. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
The immune response to stress diverges with age, with neonatal macrophages implicated in tissue regeneration versus tissue scarring and maladaptive inflammation in adults. Integral to the macrophage stress response is the recognition of hypoxia and pathogen-associated molecular patterns (PAMPs), which are often coupled. The age-specific, cell-intrinsic nature of this stress response remains vague. To uncover age-defined divergences in macrophage crosstalk potential after exposure to hypoxia and PAMPs, we interrogated the secreted proteomes of neonatal versus adult macrophages via non-biased mass spectrometry. Through this approach, we newly identified age-specific signatures in the secretomes of neonatal versus adult macrophages in response to hypoxia and the prototypical PAMP, lipopolysaccharide (LPS). Neonatal macrophages polarized to an anti-inflammatory, regenerative phenotype protective against apoptosis and oxidative stress, dependent on hypoxia inducible transcription factor-1α ( HIF-1α). In contrast, adult macrophages adopted a pro-inflammatory, glycolytic phenotypic signature consistent with pathogen killing. Taken together, these data uncover fundamental age and HIF-1α dependent macrophage programs that may be targeted to calibrate the innate immune response during stress and inflammation. |
| التعليقات: |
Update in: Cell Immunol. 2024 Aug 2;403-404:104861. doi: 10.1016/j.cellimm.2024.104861. (PMID: 39098245) |
| تواريخ الأحداث: |
Date Created: 20240507 Latest Revision: 20240806 |
| رمز التحديث: |
20240806 |
| مُعرف محوري في PubMed: |
PMC11071477 |
| DOI: |
10.1101/2024.04.24.591000 |
| PMID: |
38712137 |
| قاعدة البيانات: |
MEDLINE |
