دورية أكاديمية
Dopaminergic mesolimbic structural reserve is positively linked to better outcome after severe stroke.
| العنوان: | Dopaminergic mesolimbic structural reserve is positively linked to better outcome after severe stroke. |
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| المؤلفون: | Asmussen L; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Frey BM; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Frontzkowski LK; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Wróbel PP; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Grigutsch LS; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Choe CU; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Bönstrup M; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany.; University Medical Center Leipzig, Department of Neurology, 04103 Leipzig, Germany., Cheng B; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Thomalla G; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Quandt F; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Gerloff C; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany., Schulz R; University Medical Center Hamburg-Eppendorf, Department of Neurology, 20246 Hamburg, Germany. |
| المصدر: | Brain communications [Brain Commun] 2024 Apr 09; Vol. 6 (3), pp. fcae122. Date of Electronic Publication: 2024 Apr 09 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Oxford University Press, [2019]- |
| مستخلص: | The concept of brain reserve capacity has emerged in stroke recovery research in recent years. Imaging-based biomarkers of brain health have helped to better understand outcome variability in clinical cohorts. Still, outcome inferences are far from being satisfactory, particularly in patients with severe initial deficits. Neurorehabilitation after stroke is a complex process, comprising adaption and learning processes, which, on their part, are critically influenced by motivational and reward-related cognitive processes. Amongst others, dopaminergic neurotransmission is a key contributor to these mechanisms. The question arises, whether the amount of structural reserve capacity in the dopaminergic system might inform about outcome variability after severe stroke. For this purpose, this study analysed imaging and clinical data of 42 severely impaired acute stroke patients. Brain volumetry was performed within the first 2 weeks after the event using the Computational Anatomy Toolbox CAT12, grey matter volume estimates were collected for seven key areas of the human dopaminergic system along the mesocortical, mesolimbic and nigrostriatal pathways. Ordinal logistic regression models related regional volumes to the functional outcome, operationalized by the modified Rankin Scale, obtained 3-6 months after stroke. Models were adjusted for age, lesion volume and initial impairment. The main finding was that larger volumes of the amygdala and the nucleus accumbens at baseline were positively associated with a more favourable outcome. These data suggest a link between the structural state of mesolimbic key areas contributing to motor learning, motivational and reward-related brain networks and potentially the success of neurorehabilitation. They might also provide novel evidence to reconsider dopaminergic interventions particularly in severely impaired stroke patients to enhance recovery after stroke. Competing Interests: The authors report no competing interests. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.) |
| التعليقات: | Erratum in: Brain Commun. 2024 Jun 06;6(3):fcae191. doi: 10.1093/braincomms/fcae191. (PMID: 38846533) |
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| فهرسة مساهمة: | Keywords: brain reserve; cognition; dopamine; grey matter; voxel-based morphometry |
| تواريخ الأحداث: | Date Created: 20240507 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC11073754 |
| DOI: | 10.1093/braincomms/fcae122 |
| PMID: | 38712322 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2632-1297 |
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| DOI: | 10.1093/braincomms/fcae122 |